Expression of NAPSA in cancer - Summary - The Human Protein Atlas

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NAPSA

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NAPSA
Gene description	Napsin A aspartic peptidase
Protein class	Enzymes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (lung cancer)
HPA (cell line):	Cell line enriched (U-698)
HPA (normal tissue):	Tissue enriched (lung)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in lung and kidney.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 4 antibodies. HPA045280 , HPA047236 , HPA047744 , CAB009591
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (lung cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045280	HPA047236	HPA047744	CAB009591

GENE INFORMATION
Gene name	NAPSA (HGNC Symbol)
Synonyms	KAP, Kdap, NAP1, NAPA
Description	Napsin A aspartic peptidase (HGNC Symbol)
Entrez gene summary	The activation peptides of aspartic proteinases plays role as inhibitors of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully functional, glycosylated aspartic proteinase precursor containing an RGD motif and an additional 18 residues at its C-terminus. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	50358477 - 50365830
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131400 (version 83.38)
Entrez gene	9476
UniProt	O96009 (UniProt - Evidence at protein level)
neXtProt	NX_O96009
Antibodypedia	NAPSA antibodies

PROTEIN BROWSER

NAPSA-001	NAPSA-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NAPSA-001 ENSP00000253719 ENST00000253719	O96009 [Direct mapping] Napsin-A Show all	Enzymes Peptidases Aspartic-type peptidases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004175 [endopeptidase activity] GO:0004190 [aspartic-type endopeptidase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005764 [lysosome] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0030163 [protein catabolic process] GO:0033619 [membrane protein proteolysis] GO:0043129 [surfactant homeostasis] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] GO:0097208 [alveolar lamellar body] GO:0097486 [multivesicular body lumen] Show all	420 aa 45.4 kDa	Yes	0
NAPSA-006 ENSP00000469061 ENST00000598915	M0QXC5 [Direct mapping] Napsin-A Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0030163 [protein catabolic process] Show all	268 aa 29.1 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.