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AOC3

GENERAL INFORMATION

Gene name

 AOC3

Gene description

 Amine oxidase, copper containing 3

Protein class

 Cancer-related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (Hep G2)
HPA (normal tissue):Tissue enhanced (adipose tissue)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic staining in smooth muscle, adipocytes, adrenal gland and alveolar cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 2 antibodies.
HPA000980 , CAB025797
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), colorectal cancer (unfavourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001
Colorectal cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA000980
CAB025797

GENE INFORMATION

Gene name

 AOC3 (HGNC Symbol)

Synonyms

 HPAO, VAP-1, VAP1

Description

 Amine oxidase, copper containing 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

Chromosome

 17

Cytoband

 q21.31

Chromosome location (bp)

 42851184 - 42858130

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131471 (version 83.38)

Entrez gene

 8639

UniProt

 Q16853 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16853

Antibodypedia

 AOC3 antibodies

PROTEIN BROWSER
AOC3-001
AOC3-002
AOC3-004
AOC3-005
AOC3-201
AOC3-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AOC3-001
ENSP00000312326
ENST00000308423
Q16853 [Direct mapping]
Membrane primary amine oxidase
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Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005261 [cation channel activity]
GO:0005507 [copper ion binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0006805 [xenobiotic metabolic process]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0008131 [primary amine oxidase activity]
GO:0009308 [amine metabolic process]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0046677 [response to antibiotic]
GO:0046982 [protein heterodimerization activity]
GO:0048038 [quinone binding]
GO:0052593 [tryptamine:oxygen oxidoreductase (deaminating) activity]
GO:0052594 [aminoacetone:oxygen oxidoreductase(deaminating) activity]
GO:0052595 [aliphatic-amine oxidase activity]
GO:0052596 [phenethylamine:oxygen oxidoreductase (deaminating) activity]
GO:0055114 [oxidation-reduction process]
GO:0098655 [cation transmembrane transport]
Show all
 763 aa
84.6 kDa 		Yes 0
AOC3-002
ENSP00000468632
ENST00000591562
Q16853 [Direct mapping]
Membrane primary amine oxidase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005261 [cation channel activity]
GO:0005507 [copper ion binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0006805 [xenobiotic metabolic process]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0008131 [primary amine oxidase activity]
GO:0009308 [amine metabolic process]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0046677 [response to antibiotic]
GO:0046982 [protein heterodimerization activity]
GO:0048038 [quinone binding]
GO:0052593 [tryptamine:oxygen oxidoreductase (deaminating) activity]
GO:0052594 [aminoacetone:oxygen oxidoreductase(deaminating) activity]
GO:0052595 [aliphatic-amine oxidase activity]
GO:0052596 [phenethylamine:oxygen oxidoreductase (deaminating) activity]
GO:0055114 [oxidation-reduction process]
GO:0098655 [cation transmembrane transport]
Show all
 220 aa
24.5 kDa 		No 0
AOC3-004
ENSP00000465913
ENST00000592999
K7EL47 [Direct mapping]
Membrane primary amine oxidase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005507 [copper ion binding]
GO:0008131 [primary amine oxidase activity]
GO:0009308 [amine metabolic process]
GO:0048038 [quinone binding]
GO:0055114 [oxidation-reduction process]
Show all
 152 aa
17.3 kDa 		No 0
AOC3-005
ENSP00000468043
ENST00000588033
K7EQZ5 [Direct mapping]
Membrane primary amine oxidase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005507 [copper ion binding]
GO:0008131 [primary amine oxidase activity]
GO:0009308 [amine metabolic process]
GO:0048038 [quinone binding]
GO:0055114 [oxidation-reduction process]
Show all
 112 aa
12.9 kDa 		No 0
AOC3-201
ENSP00000484312
ENST00000613571
Q16853 [Direct mapping]
Membrane primary amine oxidase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005261 [cation channel activity]
GO:0005507 [copper ion binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0006805 [xenobiotic metabolic process]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0008131 [primary amine oxidase activity]
GO:0009308 [amine metabolic process]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0046677 [response to antibiotic]
GO:0046982 [protein heterodimerization activity]
GO:0048038 [quinone binding]
GO:0052593 [tryptamine:oxygen oxidoreductase (deaminating) activity]
GO:0052594 [aminoacetone:oxygen oxidoreductase(deaminating) activity]
GO:0052595 [aliphatic-amine oxidase activity]
GO:0052596 [phenethylamine:oxygen oxidoreductase (deaminating) activity]
GO:0055114 [oxidation-reduction process]
GO:0098655 [cation transmembrane transport]
Show all
 634 aa
70.7 kDa 		Yes 0
AOC3-202
ENSP00000477686
ENST00000617500
Q16853 [Direct mapping]
Membrane primary amine oxidase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005261 [cation channel activity]
GO:0005507 [copper ion binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0006805 [xenobiotic metabolic process]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0008131 [primary amine oxidase activity]
GO:0009308 [amine metabolic process]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0046677 [response to antibiotic]
GO:0046982 [protein heterodimerization activity]
GO:0048038 [quinone binding]
GO:0052593 [tryptamine:oxygen oxidoreductase (deaminating) activity]
GO:0052594 [aminoacetone:oxygen oxidoreductase(deaminating) activity]
GO:0052595 [aliphatic-amine oxidase activity]
GO:0052596 [phenethylamine:oxygen oxidoreductase (deaminating) activity]
GO:0055114 [oxidation-reduction process]
GO:0098655 [cation transmembrane transport]
Show all
 220 aa
24.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.