We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
NDFIP1
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

NDFIP1

Gene description

Nedd4 family interacting protein 1

Protein class

Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA009682
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in head and neck cancer (unfavourable) and renal cancer (favourable).
Head and neck cancer p<0.001
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA009682

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most tumors were weakly stained or negative. Several gastric, pancreatic and liver cancers showed moderate staining.

GENE INFORMATION

Gene name

NDFIP1 (HGNC Symbol)

Synonyms

MGC10924, N4WBP5

Description

Nedd4 family interacting protein 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q31.3

Chromosome location (bp)

142108505 - 142154443

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000131507 (version 83.38)

Entrez gene

80762

UniProt

Q9BT67 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BT67

Antibodypedia

NDFIP1 antibodies

PROTEIN BROWSER

NDFIP1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NDFIP1-001
ENSP00000253814
ENST00000253814
Q9BT67 [Direct mapping]
NEDD4 family-interacting protein 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0002761 [regulation of myeloid leukocyte differentiation]
GO:0002829 [negative regulation of type 2 immune response]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005794 [Golgi apparatus]
GO:0005938 [cell cortex]
GO:0006879 [cellular iron ion homeostasis]
GO:0007034 [vacuolar transport]
GO:0007165 [signal transduction]
GO:0010008 [endosome membrane]
GO:0010629 [negative regulation of gene expression]
GO:0016021 [integral component of membrane]
GO:0030001 [metal ion transport]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0032410 [negative regulation of transporter activity]
GO:0032713 [negative regulation of interleukin-4 production]
GO:0042130 [negative regulation of T cell proliferation]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0045619 [regulation of lymphocyte differentiation]
GO:0045732 [positive regulation of protein catabolic process]
GO:0048294 [negative regulation of isotype switching to IgE isotypes]
GO:0048302 [regulation of isotype switching to IgG isotypes]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050728 [negative regulation of inflammatory response]
GO:0051224 [negative regulation of protein transport]
Show all
221 aa
24.9 kDa
Yes 3

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.