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Most tumors were weakly stained or negative. Several gastric, pancreatic and liver cancers showed moderate staining.
GENE INFORMATION
Gene name
NDFIP1 (HGNC Symbol)
Synonyms
MGC10924, N4WBP5
Description
Nedd4 family interacting protein 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins. [provided by RefSeq, Jul 2008]
Q9BT67 [Direct mapping] NEDD4 family-interacting protein 1
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane] GO:0002761 [regulation of myeloid leukocyte differentiation] GO:0002829 [negative regulation of type 2 immune response] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005794 [Golgi apparatus] GO:0005938 [cell cortex] GO:0006879 [cellular iron ion homeostasis] GO:0007034 [vacuolar transport] GO:0007165 [signal transduction] GO:0010008 [endosome membrane] GO:0010629 [negative regulation of gene expression] GO:0016021 [integral component of membrane] GO:0030001 [metal ion transport] GO:0031398 [positive regulation of protein ubiquitination] GO:0032410 [negative regulation of transporter activity] GO:0032713 [negative regulation of interleukin-4 production] GO:0042130 [negative regulation of T cell proliferation] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway] GO:0045619 [regulation of lymphocyte differentiation] GO:0045732 [positive regulation of protein catabolic process] GO:0048294 [negative regulation of isotype switching to IgE isotypes] GO:0048302 [regulation of isotype switching to IgG isotypes] GO:0048471 [perinuclear region of cytoplasm] GO:0050728 [negative regulation of inflammatory response] GO:0051224 [negative regulation of protein transport]