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The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins. [provided by RefSeq, Jul 2008]
Q9BT67 [Direct mapping] NEDD4 family-interacting protein 1
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane] GO:0002761 [regulation of myeloid leukocyte differentiation] GO:0002829 [negative regulation of type 2 immune response] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005794 [Golgi apparatus] GO:0005938 [cell cortex] GO:0006879 [cellular iron ion homeostasis] GO:0007034 [vacuolar transport] GO:0007165 [signal transduction] GO:0010008 [endosome membrane] GO:0010629 [negative regulation of gene expression] GO:0016021 [integral component of membrane] GO:0030001 [metal ion transport] GO:0031398 [positive regulation of protein ubiquitination] GO:0032410 [negative regulation of transporter activity] GO:0032713 [negative regulation of interleukin-4 production] GO:0042130 [negative regulation of T cell proliferation] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway] GO:0045619 [regulation of lymphocyte differentiation] GO:0045732 [positive regulation of protein catabolic process] GO:0048294 [negative regulation of isotype switching to IgE isotypes] GO:0048302 [regulation of isotype switching to IgG isotypes] GO:0048471 [perinuclear region of cytoplasm] GO:0050728 [negative regulation of inflammatory response] GO:0051224 [negative regulation of protein transport]
