Expression of CA6 in cancer - Summary - The Human Protein Atlas

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CA6

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CA6
Gene description	Carbonic anhydrase VI
Protein class	Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enriched (salivary gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Highly specific cytoplasmic expression in salivary gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA028550 , HPA028692
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA028550	HPA028692

GENE INFORMATION
Gene name	CA6
Synonyms
Description	Carbonic anhydrase VI (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is found only in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide though its function in saliva is unknown. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.23
Chromosome location (bp)	8945867 - 8975092
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131686 (version 83.38)
Entrez gene	765
UniProt	P23280 (UniProt - Evidence at protein level)
neXtProt	NX_P23280
Antibodypedia	CA6 antibodies

PROTEIN BROWSER

CA6-001	CA6-002	CA6-005	CA6-006	CA6-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CA6-001 ENSP00000366662 ENST00000377443	P23280 [Direct mapping] Carbonic anhydrase 6 Show all	Enzymes ENZYME proteins Lyases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001580 [detection of chemical stimulus involved in sensory perception of bitter taste] GO:0004089 [carbonate dehydratase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] GO:0015701 [bicarbonate transport] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	308 aa 35.4 kDa	Yes	0
CA6-002 ENSP00000435280 ENST00000480186	Q8N4G4 [Direct mapping] CA6 protein; Carbonic anhydrase 6 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	179 aa 19.7 kDa	Yes	0
CA6-005 ENSP00000366654 ENST00000377436	P23280 [Direct mapping] Carbonic anhydrase 6 Show all	Enzymes ENZYME proteins Lyases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001580 [detection of chemical stimulus involved in sensory perception of bitter taste] GO:0004089 [carbonate dehydratase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] GO:0015701 [bicarbonate transport] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	313 aa 35.4 kDa	Yes	0
CA6-006 ENSP00000366661 ENST00000377442	P23280 [Direct mapping] Carbonic anhydrase 6 Show all	Enzymes ENZYME proteins Lyases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001580 [detection of chemical stimulus involved in sensory perception of bitter taste] GO:0004089 [carbonate dehydratase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] GO:0015701 [bicarbonate transport] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	248 aa 28.7 kDa	Yes	0
CA6-007 ENSP00000447108 ENST00000549778	F8W148 [Direct mapping] Carbonic anhydrase 6 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] Show all	187 aa 21.1 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.