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CA6

GENERAL INFORMATION

Gene name

 CA6

Gene description

 Carbonic anhydrase VI

Protein class

 Enzymes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (salivary gland)
GTEx:Tissue enriched (skin)
FANTOM5:Tissue enriched (salivary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Highly specific cytoplasmic expression in salivary gland.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA028550 , HPA028692
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Salivary gland

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (salivary gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (salivary gland)

GENE INFORMATION

Gene name

 CA6

Synonyms

Description

 Carbonic anhydrase VI (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is found only in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide though its function in saliva is unknown. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.23

Chromosome location (bp)

 8945867 - 8975092

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131686 (version 83.38)

Entrez gene

 765

UniProt

 P23280 (UniProt - Evidence at protein level)

neXtProt

 NX_P23280

Antibodypedia

 CA6 antibodies

PROTEIN BROWSER
CA6-001
CA6-002
CA6-005
CA6-006
CA6-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CA6-001
ENSP00000366662
ENST00000377443
P23280 [Direct mapping]
Carbonic anhydrase 6
Show all
Enzymes
   ENZYME proteins
   Lyases
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001580 [detection of chemical stimulus involved in sensory perception of bitter taste]
GO:0004089 [carbonate dehydratase activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006730 [one-carbon metabolic process]
GO:0008270 [zinc ion binding]
GO:0015701 [bicarbonate transport]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 308 aa
35.4 kDa 		Yes 0
CA6-002
ENSP00000435280
ENST00000480186
Q8N4G4 [Direct mapping]
CA6 protein; Carbonic anhydrase 6
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 179 aa
19.7 kDa 		Yes 0
CA6-005
ENSP00000366654
ENST00000377436
P23280 [Direct mapping]
Carbonic anhydrase 6
Show all
Enzymes
   ENZYME proteins
   Lyases
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001580 [detection of chemical stimulus involved in sensory perception of bitter taste]
GO:0004089 [carbonate dehydratase activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006730 [one-carbon metabolic process]
GO:0008270 [zinc ion binding]
GO:0015701 [bicarbonate transport]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 313 aa
35.4 kDa 		Yes 0
CA6-006
ENSP00000366661
ENST00000377442
P23280 [Direct mapping]
Carbonic anhydrase 6
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001580 [detection of chemical stimulus involved in sensory perception of bitter taste]
GO:0004089 [carbonate dehydratase activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006730 [one-carbon metabolic process]
GO:0008270 [zinc ion binding]
GO:0015701 [bicarbonate transport]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 248 aa
28.7 kDa 		Yes 0
CA6-007
ENSP00000447108
ENST00000549778
F8W148 [Direct mapping]
Carbonic anhydrase 6
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004089 [carbonate dehydratase activity]
GO:0006730 [one-carbon metabolic process]
GO:0008270 [zinc ion binding]
Show all
 187 aa
21.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.