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PPP1R1B

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GENERAL INFORMATION

Gene name

 PPP1R1B

Gene description

 Protein phosphatase 1, regulatory (inhibitor) subunit 1B

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (SCLC-21H, CAPAN-2)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (SCLC-21H, CAPAN-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 PPP1R1B (HGNC Symbol)

Synonyms

 DARPP-32, FLJ20940

Description

 Protein phosphatase 1, regulatory (inhibitor) subunit 1B (HGNC Symbol)

Entrez gene summary

 This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Chromosome

 17

Cytoband

 q12

Chromosome location (bp)

 39626740 - 39636626

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131771 (version 83.38)

Entrez gene

 84152

UniProt

 Q9UD71 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UD71

Antibodypedia

 PPP1R1B antibodies

PROTEIN BROWSER
PPP1R1B-001
PPP1R1B-002
PPP1R1B-005
PPP1R1B-008
PPP1R1B-013
PPP1R1B-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPP1R1B-001
ENSP00000254079
ENST00000254079
Q9UD71 [Direct mapping]
Protein phosphatase 1 regulatory subunit 1B
B3KVQ9 [Target identity:100%; Query identity:100%]
Protein phosphatase 1, regulatory (Inhibitor) subunit 1B (Dopamine and cAMP regulated phosphoprotein, DARPP-32), isoform CRA_b; cDNA FLJ41117 fis, clone BRACE2006821, highly similar to Dopamine- and cAMP-regulated neuronalphospho protein; cDNA FLJ45635 fis, clone COLON2001829, highly similar to Dopamine- and cAMP-regulated neuronal phosphoprotein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001975 [response to amphetamine]
GO:0004860 [protein kinase inhibitor activity]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0004865 [protein serine/threonine phosphatase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007621 [negative regulation of female receptivity]
GO:0008542 [visual learning]
GO:0008599 [protein phosphatase type 1 regulator activity]
GO:0031748 [D1 dopamine receptor binding]
GO:0031749 [D2 dopamine receptor binding]
GO:0031750 [D3 dopamine receptor binding]
GO:0031751 [D4 dopamine receptor binding]
GO:0031752 [D5 dopamine receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0043025 [neuronal cell body]
GO:0043086 [negative regulation of catalytic activity]
GO:0050790 [regulation of catalytic activity]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 204 aa
23 kDa 		No 0
PPP1R1B-002
ENSP00000377810
ENST00000394267
Q9UD71 [Direct mapping]
Protein phosphatase 1 regulatory subunit 1B
A0A024R1R3 [Target identity:100%; Query identity:100%]
Protein phosphatase 1, regulatory (Inhibitor) subunit 1B (Dopamine and cAMP regulated phosphoprotein, DARPP-32), isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004860 [protein kinase inhibitor activity]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0004865 [protein serine/threonine phosphatase inhibitor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0008599 [protein phosphatase type 1 regulator activity]
GO:0035556 [intracellular signal transduction]
GO:0043086 [negative regulation of catalytic activity]
GO:0050790 [regulation of catalytic activity]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 168 aa
18.7 kDa 		No 0
PPP1R1B-005
ENSP00000377808
ENST00000394265
Q9UD71 [Direct mapping]
Protein phosphatase 1 regulatory subunit 1B
A0A024R1R3 [Target identity:100%; Query identity:100%]
Protein phosphatase 1, regulatory (Inhibitor) subunit 1B (Dopamine and cAMP regulated phosphoprotein, DARPP-32), isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004860 [protein kinase inhibitor activity]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0004865 [protein serine/threonine phosphatase inhibitor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0008599 [protein phosphatase type 1 regulator activity]
GO:0035556 [intracellular signal transduction]
GO:0043086 [negative regulation of catalytic activity]
GO:0050790 [regulation of catalytic activity]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 168 aa
18.7 kDa 		No 0
PPP1R1B-008
ENSP00000462841
ENST00000579000
J3KT77 [Direct mapping]
Protein phosphatase 1 regulatory subunit 1B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004864 [protein phosphatase inhibitor activity]
GO:0004865 [protein serine/threonine phosphatase inhibitor activity]
GO:0005737 [cytoplasm]
GO:0007165 [signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043086 [negative regulation of catalytic activity]
Show all
 171 aa
19.3 kDa 		No 0
PPP1R1B-013
ENSP00000462137
ENST00000580825
Q9UD71 [Direct mapping]
Protein phosphatase 1 regulatory subunit 1B
B3KVQ9 [Target identity:100%; Query identity:100%]
Protein phosphatase 1, regulatory (Inhibitor) subunit 1B (Dopamine and cAMP regulated phosphoprotein, DARPP-32), isoform CRA_b; cDNA FLJ41117 fis, clone BRACE2006821, highly similar to Dopamine- and cAMP-regulated neuronalphospho protein; cDNA FLJ45635 fis, clone COLON2001829, highly similar to Dopamine- and cAMP-regulated neuronal phosphoprotein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004860 [protein kinase inhibitor activity]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0004865 [protein serine/threonine phosphatase inhibitor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0008599 [protein phosphatase type 1 regulator activity]
GO:0035556 [intracellular signal transduction]
GO:0043086 [negative regulation of catalytic activity]
GO:0050790 [regulation of catalytic activity]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 204 aa
23 kDa 		No 0
PPP1R1B-014
ENSP00000462522
ENST00000582680
J3KSJ8 [Direct mapping]
Protein phosphatase 1 regulatory subunit 1B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004864 [protein phosphatase inhibitor activity]
GO:0004865 [protein serine/threonine phosphatase inhibitor activity]
GO:0005737 [cytoplasm]
GO:0007165 [signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043086 [negative regulation of catalytic activity]
Show all
 145 aa
16.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.