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PPP1R1B

GENERAL INFORMATION

Gene name

 PPP1R1B

Gene description

 Protein phosphatase 1, regulatory (inhibitor) subunit 1B

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Group enriched (CAPAN-2, SCLC-21H)
HPA (normal tissue):Tissue enhanced (colon, rectum)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA048630 , HPA061142 , CAB004026
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Pancreatic cancer

STAINING SUMMARY
HPA048630
HPA061142
CAB004026

GENE INFORMATION

Gene name

 PPP1R1B (HGNC Symbol)

Synonyms

 DARPP-32, FLJ20940

Description

 Protein phosphatase 1, regulatory (inhibitor) subunit 1B (HGNC Symbol)

Entrez gene summary

 This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Chromosome

 17

Cytoband

 q12

Chromosome location (bp)

 39626740 - 39636626

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131771 (version 83.38)

Entrez gene

 84152

UniProt

 Q9UD71 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UD71

Antibodypedia

 PPP1R1B antibodies

PROTEIN BROWSER
PPP1R1B-001
PPP1R1B-002
PPP1R1B-005
PPP1R1B-008
PPP1R1B-013
PPP1R1B-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPP1R1B-001
ENSP00000254079
ENST00000254079
Q9UD71 [Direct mapping]
Protein phosphatase 1 regulatory subunit 1B
B3KVQ9 [Target identity:100%; Query identity:100%]
Protein phosphatase 1, regulatory (Inhibitor) subunit 1B (Dopamine and cAMP regulated phosphoprotein, DARPP-32), isoform CRA_b; cDNA FLJ41117 fis, clone BRACE2006821, highly similar to Dopamine- and cAMP-regulated neuronalphospho protein; cDNA FLJ45635 fis, clone COLON2001829, highly similar to Dopamine- and cAMP-regulated neuronal phosphoprotein
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001975 [response to amphetamine]
GO:0004860 [protein kinase inhibitor activity]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0004865 [protein serine/threonine phosphatase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007621 [negative regulation of female receptivity]
GO:0008542 [visual learning]
GO:0008599 [protein phosphatase type 1 regulator activity]
GO:0031748 [D1 dopamine receptor binding]
GO:0031749 [D2 dopamine receptor binding]
GO:0031750 [D3 dopamine receptor binding]
GO:0031751 [D4 dopamine receptor binding]
GO:0031752 [D5 dopamine receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0043025 [neuronal cell body]
GO:0043086 [negative regulation of catalytic activity]
GO:0050790 [regulation of catalytic activity]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
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 204 aa
23 kDa 		No 0
PPP1R1B-002
ENSP00000377810
ENST00000394267
Q9UD71 [Direct mapping]
Protein phosphatase 1 regulatory subunit 1B
A0A024R1R3 [Target identity:100%; Query identity:100%]
Protein phosphatase 1, regulatory (Inhibitor) subunit 1B (Dopamine and cAMP regulated phosphoprotein, DARPP-32), isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004860 [protein kinase inhibitor activity]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0004865 [protein serine/threonine phosphatase inhibitor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0008599 [protein phosphatase type 1 regulator activity]
GO:0035556 [intracellular signal transduction]
GO:0043086 [negative regulation of catalytic activity]
GO:0050790 [regulation of catalytic activity]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
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 168 aa
18.7 kDa 		No 0
PPP1R1B-005
ENSP00000377808
ENST00000394265
Q9UD71 [Direct mapping]
Protein phosphatase 1 regulatory subunit 1B
A0A024R1R3 [Target identity:100%; Query identity:100%]
Protein phosphatase 1, regulatory (Inhibitor) subunit 1B (Dopamine and cAMP regulated phosphoprotein, DARPP-32), isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004860 [protein kinase inhibitor activity]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0004865 [protein serine/threonine phosphatase inhibitor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0008599 [protein phosphatase type 1 regulator activity]
GO:0035556 [intracellular signal transduction]
GO:0043086 [negative regulation of catalytic activity]
GO:0050790 [regulation of catalytic activity]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
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 168 aa
18.7 kDa 		No 0
PPP1R1B-008
ENSP00000462841
ENST00000579000
J3KT77 [Direct mapping]
Protein phosphatase 1 regulatory subunit 1B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004864 [protein phosphatase inhibitor activity]
GO:0004865 [protein serine/threonine phosphatase inhibitor activity]
GO:0005737 [cytoplasm]
GO:0007165 [signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043086 [negative regulation of catalytic activity]
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 171 aa
19.3 kDa 		No 0
PPP1R1B-013
ENSP00000462137
ENST00000580825
Q9UD71 [Direct mapping]
Protein phosphatase 1 regulatory subunit 1B
B3KVQ9 [Target identity:100%; Query identity:100%]
Protein phosphatase 1, regulatory (Inhibitor) subunit 1B (Dopamine and cAMP regulated phosphoprotein, DARPP-32), isoform CRA_b; cDNA FLJ41117 fis, clone BRACE2006821, highly similar to Dopamine- and cAMP-regulated neuronalphospho protein; cDNA FLJ45635 fis, clone COLON2001829, highly similar to Dopamine- and cAMP-regulated neuronal phosphoprotein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004860 [protein kinase inhibitor activity]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0004865 [protein serine/threonine phosphatase inhibitor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0008599 [protein phosphatase type 1 regulator activity]
GO:0035556 [intracellular signal transduction]
GO:0043086 [negative regulation of catalytic activity]
GO:0050790 [regulation of catalytic activity]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 204 aa
23 kDa 		No 0
PPP1R1B-014
ENSP00000462522
ENST00000582680
J3KSJ8 [Direct mapping]
Protein phosphatase 1 regulatory subunit 1B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004864 [protein phosphatase inhibitor activity]
GO:0004865 [protein serine/threonine phosphatase inhibitor activity]
GO:0005737 [cytoplasm]
GO:0007165 [signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043086 [negative regulation of catalytic activity]
Show all
 145 aa
16.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.