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PRKAB2

GENERAL INFORMATION

Gene name

 PRKAB2

Gene description

 Protein kinase, AMP-activated, beta 2 non-catalytic subunit

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA044342
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (unfavourable), breast cancer (unfavourable) and head and neck cancer (unfavourable).
Thyroid cancer p<0.001
Breast cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044342

GENE INFORMATION

Gene name

 PRKAB2

Synonyms

Description

 Protein kinase, AMP-activated, beta 2 non-catalytic subunit (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]

Chromosome

 1

Cytoband

 q21.1

Chromosome location (bp)

 147155106 - 147172550

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131791 (version 83.38)

Entrez gene

 5565

UniProt

 O43741 (UniProt - Evidence at protein level)

neXtProt

 NX_O43741

Antibodypedia

 PRKAB2 antibodies

PROTEIN BROWSER
PRKAB2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRKAB2-001
ENSP00000254101
ENST00000254101
O43741 [Direct mapping]
5'-AMP-activated protein kinase subunit beta-2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004679 [AMP-activated protein kinase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005952 [cAMP-dependent protein kinase complex]
GO:0006112 [energy reserve metabolic process]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0006633 [fatty acid biosynthetic process]
GO:0006853 [carnitine shuttle]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0008286 [insulin receptor signaling pathway]
GO:0010467 [gene expression]
GO:0016236 [macroautophagy]
GO:0019901 [protein kinase binding]
GO:0031588 [nucleotide-activated protein kinase complex]
GO:0042304 [regulation of fatty acid biosynthetic process]
GO:0042802 [identical protein binding]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045859 [regulation of protein kinase activity]
GO:0061024 [membrane organization]
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 272 aa
30.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.