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PRKAB2

GENERAL INFORMATION

Gene name

 PRKAB2

Gene description

 Protein kinase, AMP-activated, beta 2 non-catalytic subunit

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA044342
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PRKAB2

Synonyms

Description

 Protein kinase, AMP-activated, beta 2 non-catalytic subunit (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]

Chromosome

 1

Cytoband

 q21.1

Chromosome location (bp)

 147155106 - 147172550

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131791 (version 83.38)

Entrez gene

 5565

UniProt

 O43741 (UniProt - Evidence at protein level)

neXtProt

 NX_O43741

Antibodypedia

 PRKAB2 antibodies

PROTEIN BROWSER
PRKAB2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRKAB2-001
ENSP00000254101
ENST00000254101
O43741 [Direct mapping]
5'-AMP-activated protein kinase subunit beta-2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004679 [AMP-activated protein kinase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005952 [cAMP-dependent protein kinase complex]
GO:0006112 [energy reserve metabolic process]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0006633 [fatty acid biosynthetic process]
GO:0006853 [carnitine shuttle]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0008286 [insulin receptor signaling pathway]
GO:0010467 [gene expression]
GO:0016236 [macroautophagy]
GO:0019901 [protein kinase binding]
GO:0031588 [nucleotide-activated protein kinase complex]
GO:0042304 [regulation of fatty acid biosynthetic process]
GO:0042802 [identical protein binding]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045859 [regulation of protein kinase activity]
GO:0061024 [membrane organization]
Show all
 272 aa
30.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.