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PDHA1

GENERAL INFORMATION

Gene name

 PDHA1

Gene description

 Pyruvate dehydrogenase (lipoamide) alpha 1

Protein class

 Citric acid cycle related proteins
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Granular cytoplasmic expression in most cell types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 3 antibodies.
HPA047487 , HPA047864 , HPA063053
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA047487
HPA047864
HPA063053

GENE INFORMATION

Gene name

 PDHA1 (HGNC Symbol)

Synonyms

 PDHA

Description

 Pyruvate dehydrogenase (lipoamide) alpha 1 (HGNC Symbol)

Entrez gene summary

 The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

Chromosome

 X

Cytoband

 p22.12

Chromosome location (bp)

 19343893 - 19361705

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131828 (version 83.38)

Entrez gene

 5160

UniProt

 P08559 (UniProt - Evidence at protein level)

neXtProt

 NX_P08559

Antibodypedia

 PDHA1 antibodies

PROTEIN BROWSER
PDHA1-001
PDHA1-002
PDHA1-004
PDHA1-008
PDHA1-009
PDHA1-010
PDHA1-201
PDHA1-202
PDHA1-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDHA1-001
ENSP00000369133
ENST00000379805
Q5JPU0 [Direct mapping]
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016624 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor]
GO:0055114 [oxidation-reduction process]
Show all
 180 aa
19.8 kDa 		No 0
PDHA1-002
ENSP00000369132
ENST00000379804
Q5JPU3 [Direct mapping]
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
Show all
Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016624 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor]
GO:0055114 [oxidation-reduction process]
Show all
 109 aa
12.6 kDa 		No 0
PDHA1-004
ENSP00000394382
ENST00000422285
P08559 [Direct mapping]
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
A0A024RBX9 [Target identity:100%; Query identity:100%]
Pyruvate dehydrogenase E1 component subunit alpha
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Citric acid cycle related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004738 [pyruvate dehydrogenase activity]
GO:0004739 [pyruvate dehydrogenase (acetyl-transferring) activity]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006006 [glucose metabolic process]
GO:0006086 [acetyl-CoA biosynthetic process from pyruvate]
GO:0006090 [pyruvate metabolic process]
GO:0006099 [tricarboxylic acid cycle]
GO:0008152 [metabolic process]
GO:0010510 [regulation of acetyl-CoA biosynthetic process from pyruvate]
GO:0016624 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045254 [pyruvate dehydrogenase complex]
Show all
 390 aa
43.3 kDa 		No 0
PDHA1-008
ENSP00000348062
ENST00000355808
Q5JPT9 [Direct mapping]
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
Show all
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016624 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor]
GO:0055114 [oxidation-reduction process]
Show all
 204 aa
22.3 kDa 		No 0
PDHA1-009
ENSP00000406473
ENST00000423505
Q5JPU1 [Direct mapping]
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016624 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor]
GO:0055114 [oxidation-reduction process]
Show all
 205 aa
22.8 kDa 		Yes 0
PDHA1-010
ENSP00000404616
ENST00000417819
Q5JPU2 [Direct mapping]
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 121 aa
13.8 kDa 		Yes 0
PDHA1-201
ENSP00000369134
ENST00000379806
P08559 [Direct mapping]
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Citric acid cycle related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004738 [pyruvate dehydrogenase activity]
GO:0004739 [pyruvate dehydrogenase (acetyl-transferring) activity]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006006 [glucose metabolic process]
GO:0006086 [acetyl-CoA biosynthetic process from pyruvate]
GO:0006090 [pyruvate metabolic process]
GO:0006099 [tricarboxylic acid cycle]
GO:0008152 [metabolic process]
GO:0010510 [regulation of acetyl-CoA biosynthetic process from pyruvate]
GO:0016624 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor]
GO:0034604 [pyruvate dehydrogenase (NAD+) activity]
GO:0043209 [myelin sheath]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045254 [pyruvate dehydrogenase complex]
GO:0061732 [mitochondrial acetyl-CoA biosynthetic process from pyruvate]
Show all
 428 aa
47.6 kDa 		Yes 0
PDHA1-202
ENSP00000440761
ENST00000540249
P08559 [Direct mapping]
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Citric acid cycle related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004738 [pyruvate dehydrogenase activity]
GO:0004739 [pyruvate dehydrogenase (acetyl-transferring) activity]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006006 [glucose metabolic process]
GO:0006086 [acetyl-CoA biosynthetic process from pyruvate]
GO:0006090 [pyruvate metabolic process]
GO:0006099 [tricarboxylic acid cycle]
GO:0008152 [metabolic process]
GO:0010510 [regulation of acetyl-CoA biosynthetic process from pyruvate]
GO:0016624 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045254 [pyruvate dehydrogenase complex]
Show all
 359 aa
40.2 kDa 		No 0
PDHA1-203
ENSP00000438550
ENST00000545074
P08559 [Direct mapping]
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Citric acid cycle related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004738 [pyruvate dehydrogenase activity]
GO:0004739 [pyruvate dehydrogenase (acetyl-transferring) activity]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006006 [glucose metabolic process]
GO:0006086 [acetyl-CoA biosynthetic process from pyruvate]
GO:0006090 [pyruvate metabolic process]
GO:0006099 [tricarboxylic acid cycle]
GO:0008152 [metabolic process]
GO:0010510 [regulation of acetyl-CoA biosynthetic process from pyruvate]
GO:0016624 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045254 [pyruvate dehydrogenase complex]
Show all
 397 aa
44.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.