Expression of ZSCAN5A in cancer - Summary - The Human Protein Atlas

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ZSCAN5A

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ZSCAN5A
Gene description	Zinc finger and SCAN domain containing 5A
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Expressed in all
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in selected tissues, most abundant in Leydig cells of testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 3 antibodies. HPA041263 , HPA043123 , HPA046836
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041263	HPA043123	HPA046836

GENE INFORMATION
Gene name	ZSCAN5A (HGNC Symbol)
Synonyms	MGC4161, ZNF495, ZSCAN5
Description	Zinc finger and SCAN domain containing 5A (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.43
Chromosome location (bp)	56219670 - 56368383
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131848 (version 83.38)
Entrez gene	79149
UniProt	Q9BUG6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9BUG6
Antibodypedia	ZSCAN5A antibodies

PROTEIN BROWSER

ZSCAN5A-001	ZSCAN5A-002	ZSCAN5A-004	ZSCAN5A-005	ZSCAN5A-008	ZSCAN5A-009	ZSCAN5A-010	ZSCAN5A-019	ZSCAN5A-020

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZSCAN5A-001 ENSP00000467238 ENST00000592355	A0A0C4DGQ1 [Direct mapping] Zinc finger and SCAN domain-containing protein 5A Show all	Predicted intracellular proteins Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003676 [nucleic acid binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] Show all	495 aa 55.8 kDa	No	0
ZSCAN5A-002 ENSP00000375593 ENST00000391713	Q9BUG6 [Direct mapping] Zinc finger and SCAN domain-containing protein 5A A0A024R4S6 [Target identity:100%; Query identity:100%] Zinc finger and SCAN domain containing 5, isoform CRA_a Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] Show all	496 aa 55.9 kDa	No	0
ZSCAN5A-004 ENSP00000467631 ENST00000587340	Q9BUG6 [Direct mapping] Zinc finger and SCAN domain-containing protein 5A A0A024R4S6 [Target identity:100%; Query identity:100%] Zinc finger and SCAN domain containing 5, isoform CRA_a Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] Show all	496 aa 55.9 kDa	No	0
ZSCAN5A-005 ENSP00000466445 ENST00000587492	K7EMC4 [Direct mapping] Zinc finger and SCAN domain-containing protein 5A Show all	Predicted intracellular proteins Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003676 [nucleic acid binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] Show all	350 aa 39.1 kDa	No	0
ZSCAN5A-008 ENSP00000468797 ENST00000592509	K7ESN6 [Direct mapping] Zinc finger and SCAN domain-containing protein 5A Show all	Predicted intracellular proteins Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	105 aa 12 kDa	No	0
ZSCAN5A-009 ENSP00000468008 ENST00000588955	K7EQW6 [Direct mapping] Zinc finger and SCAN domain-containing protein 5A Show all	Predicted intracellular proteins Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	84 aa 9.5 kDa	No	0
ZSCAN5A-010 ENSP00000466830 ENST00000592679	K7EN85 [Direct mapping] Zinc finger and SCAN domain-containing protein 5A Show all	Predicted intracellular proteins Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	38 aa 4 kDa	No	0
ZSCAN5A-019 ENSP00000464936 ENST00000593106	K7EIX9 [Direct mapping] Zinc finger and SCAN domain-containing protein 5A Show all	Predicted intracellular proteins Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	190 aa 20.5 kDa	No	0
ZSCAN5A-020 ENSP00000468675 ENST00000588442	K7ESE4 [Direct mapping] Zinc finger and SCAN domain-containing protein 5A Show all	Predicted intracellular proteins Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	42 aa 4.5 kDa	No	0

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