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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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LLGL1
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

LLGL1

Gene description

Lethal giant larvae homolog 1 (Drosophila)

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 2 antibodies.
HPA022924 , HPA023569
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PROGNOSTIC SUMMARY

Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA022924
HPA023569

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignant cells displayed moderate cytoplasmic immunoreactivity. A majority of Renal carcinomas, lung cancers, malignant melanomas and lymphomas were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant tissues showed moderate cytoplasmic staining with a granular pattern. Colorectal, breast, testicular, thyroid and gastric cancers displayed moderate to strong cytoplasmic staining.

GENE INFORMATION

Gene name

LLGL1 (HGNC Symbol)

Synonyms

DLG4, HUGL, HUGL-1, LLGL

Description

Lethal giant larvae homolog 1 (Drosophila) (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

p11.2

Chromosome location (bp)

18225587 - 18244875

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000131899 (version 83.38)

Entrez gene

3996

UniProt

Q15334 (UniProt - Evidence at protein level)

neXtProt

NX_Q15334

Antibodypedia

LLGL1 antibodies

PROTEIN BROWSER

LLGL1-001
LLGL1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LLGL1-001
ENSP00000321537
ENST00000316843
Q15334 [Direct mapping]
Lethal(2) giant larvae protein homolog 1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000137 [Golgi cis cisterna]
GO:0005096 [GTPase activator activity]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0006887 [exocytosis]
GO:0006893 [Golgi to plasma membrane transport]
GO:0007409 [axonogenesis]
GO:0008593 [regulation of Notch signaling pathway]
GO:0017137 [Rab GTPase binding]
GO:0019901 [protein kinase binding]
GO:0022008 [neurogenesis]
GO:0030424 [axon]
GO:0030864 [cortical actin cytoskeleton]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0031901 [early endosome membrane]
GO:0032588 [trans-Golgi network membrane]
GO:0032878 [regulation of establishment or maintenance of cell polarity]
GO:0043547 [positive regulation of GTPase activity]
GO:0050708 [regulation of protein secretion]
GO:0051294 [establishment of spindle orientation]
Show all
1064 aa
115.4 kDa
No 0
LLGL1-201
ENSP00000480006
ENST00000621229
A0A087WW77 [Direct mapping]
Lethal(2) giant larvae protein homolog 1
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
1056 aa
114.4 kDa
No 0

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