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LLGL1

GENERAL INFORMATION

Gene name

 LLGL1

Gene description

 Lethal giant larvae homolog 1 (Drosophila)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex)
GTEx:Expressed in all
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA022924 , HPA023569
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 LLGL1 (HGNC Symbol)

Synonyms

 DLG4, HUGL, HUGL-1, LLGL

Description

 Lethal giant larvae homolog 1 (Drosophila) (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 p11.2

Chromosome location (bp)

 18225587 - 18244875

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131899 (version 83.38)

Entrez gene

 3996

UniProt

 Q15334 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15334

Antibodypedia

 LLGL1 antibodies

PROTEIN BROWSER
LLGL1-001
LLGL1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LLGL1-001
ENSP00000321537
ENST00000316843
Q15334 [Direct mapping]
Lethal(2) giant larvae protein homolog 1
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000137 [Golgi cis cisterna]
GO:0005096 [GTPase activator activity]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0006887 [exocytosis]
GO:0006893 [Golgi to plasma membrane transport]
GO:0007409 [axonogenesis]
GO:0008593 [regulation of Notch signaling pathway]
GO:0017137 [Rab GTPase binding]
GO:0019901 [protein kinase binding]
GO:0022008 [neurogenesis]
GO:0030424 [axon]
GO:0030864 [cortical actin cytoskeleton]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0031901 [early endosome membrane]
GO:0032588 [trans-Golgi network membrane]
GO:0032878 [regulation of establishment or maintenance of cell polarity]
GO:0043547 [positive regulation of GTPase activity]
GO:0050708 [regulation of protein secretion]
GO:0051294 [establishment of spindle orientation]
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 1064 aa
115.4 kDa 		No 0
LLGL1-201
ENSP00000480006
ENST00000621229
A0A087WW77 [Direct mapping]
Lethal(2) giant larvae protein homolog 1
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 1056 aa
114.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.