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CC2D1A

GENERAL INFORMATION

Gene name

 CC2D1A

Gene description

 Coiled-coil and C2 domain containing 1A

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA005436 , CAB015220
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CC2D1A (HGNC Symbol)

Synonyms

 FLJ20241, MRT3

Description

 Coiled-coil and C2 domain containing 1A (HGNC Symbol)

Entrez gene summary

 This gene encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. The DNA binding and transcriptional repressor activities of the protein are inhibited by calcium. A mutation in this gene results in nonsyndromic mental retardation-3.[provided by RefSeq, Oct 2009]

Chromosome

 19

Cytoband

 p13.12

Chromosome location (bp)

 13906201 - 13930879

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132024 (version 83.38)

Entrez gene

 54862

UniProt

 Q6P1N0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6P1N0

Antibodypedia

 CC2D1A antibodies

PROTEIN BROWSER
CC2D1A-001
CC2D1A-005
CC2D1A-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CC2D1A-001
ENSP00000313601
ENST00000318003
Q6P1N0 [Direct mapping]
Coiled-coil and C2 domain-containing protein 1A
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0070062 [extracellular exosome]
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 951 aa
104.1 kDa 		No 0
CC2D1A-005
ENSP00000466586
ENST00000587508
K7EMP1 [Direct mapping]
Coiled-coil and C2 domain-containing protein 1A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
Show all
 405 aa
45.8 kDa 		No 0
CC2D1A-010
ENSP00000467526
ENST00000589606
Q6P1N0 [Direct mapping]
Coiled-coil and C2 domain-containing protein 1A
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0070062 [extracellular exosome]
Show all
 950 aa
103.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.