Expression of TRIM22 in cancer - Summary - The Human Protein Atlas

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TRIM22

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TRIM22
Gene description	Tripartite motif containing 22
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA003307 , HPA003575
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003307	HPA003575

GENE INFORMATION
Gene name	TRIM22 (HGNC Symbol)
Synonyms	GPSTAF50, RNF94, STAF50
Description	Tripartite motif containing 22 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Chromosome	11
Cytoband	p15.4
Chromosome location (bp)	5689689 - 5737089
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132274 (version 83.38)
Entrez gene	10346
UniProt	Q8IYM9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IYM9
Antibodypedia	TRIM22 antibodies

PROTEIN BROWSER

TRIM22-001	TRIM22-003	TRIM22-005	TRIM22-006	TRIM22-008	TRIM22-010	TRIM22-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRIM22-001 ENSP00000369299 ENST00000379965	Q8IYM9 [Direct mapping] E3 ubiquitin-protein ligase TRIM22 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006955 [immune response] GO:0008270 [zinc ion binding] GO:0009615 [response to virus] GO:0015030 [Cajal body] GO:0016032 [viral process] GO:0016567 [protein ubiquitination] GO:0016607 [nuclear speck] GO:0016874 [ligase activity] GO:0019221 [cytokine-mediated signaling pathway] GO:0019901 [protein kinase binding] GO:0030674 [protein binding, bridging] GO:0032880 [regulation of protein localization] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0070206 [protein trimerization] GO:1903507 [negative regulation of nucleic acid-templated transcription] Show all	498 aa 56.9 kDa	No	0
TRIM22-003 ENSP00000400417 ENST00000425490	C9J060 [Direct mapping] E3 ubiquitin-protein ligase TRIM22 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0008270 [zinc ion binding] Show all	203 aa 23.7 kDa	No	0
TRIM22-005 ENSP00000396849 ENST00000414641	C9JIU5 [Direct mapping] E3 ubiquitin-protein ligase TRIM22 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0008270 [zinc ion binding] Show all	227 aa 26.3 kDa	No	0
TRIM22-006 ENSP00000393250 ENST00000454828	C9JWC5 [Direct mapping] E3 ubiquitin-protein ligase TRIM22 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0008270 [zinc ion binding] Show all	305 aa 34.9 kDa	No	0
TRIM22-008 ENSP00000406412 ENST00000450670	H7C2K0 [Direct mapping] E3 ubiquitin-protein ligase TRIM22 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		63 aa 7.6 kDa	No	0
TRIM22-010 ENSP00000409991 ENST00000429063	H7C376 [Direct mapping] E3 ubiquitin-protein ligase TRIM22 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		37 aa 4.3 kDa	No	0
TRIM22-011 ENSP00000404204 ENST00000444844	H7C262 [Direct mapping] E3 ubiquitin-protein ligase TRIM22 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		38 aa 4.4 kDa	No	0

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The Human Protein Atlas

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