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TRIM22

GENERAL INFORMATION

Gene name

 TRIM22

Gene description

 Tripartite motif containing 22

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear and cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA003307 , HPA003575
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TRIM22 (HGNC Symbol)

Synonyms

 GPSTAF50, RNF94, STAF50

Description

 Tripartite motif containing 22 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

Chromosome

 11

Cytoband

 p15.4

Chromosome location (bp)

 5689689 - 5737089

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132274 (version 83.38)

Entrez gene

 10346

UniProt

 Q8IYM9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IYM9

Antibodypedia

 TRIM22 antibodies

PROTEIN BROWSER
TRIM22-001
TRIM22-003
TRIM22-005
TRIM22-006
TRIM22-008
TRIM22-010
TRIM22-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRIM22-001
ENSP00000369299
ENST00000379965
Q8IYM9 [Direct mapping]
E3 ubiquitin-protein ligase TRIM22
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006955 [immune response]
GO:0008270 [zinc ion binding]
GO:0009615 [response to virus]
GO:0015030 [Cajal body]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0016607 [nuclear speck]
GO:0016874 [ligase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0030674 [protein binding, bridging]
GO:0032880 [regulation of protein localization]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0070206 [protein trimerization]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
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 498 aa
56.9 kDa 		No 0
TRIM22-003
ENSP00000400417
ENST00000425490
C9J060 [Direct mapping]
E3 ubiquitin-protein ligase TRIM22
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0008270 [zinc ion binding]
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 203 aa
23.7 kDa 		No 0
TRIM22-005
ENSP00000396849
ENST00000414641
C9JIU5 [Direct mapping]
E3 ubiquitin-protein ligase TRIM22
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0008270 [zinc ion binding]
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 227 aa
26.3 kDa 		No 0
TRIM22-006
ENSP00000393250
ENST00000454828
C9JWC5 [Direct mapping]
E3 ubiquitin-protein ligase TRIM22
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0008270 [zinc ion binding]
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 305 aa
34.9 kDa 		No 0
TRIM22-008
ENSP00000406412
ENST00000450670
H7C2K0 [Direct mapping]
E3 ubiquitin-protein ligase TRIM22
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 63 aa
7.6 kDa 		No 0
TRIM22-010
ENSP00000409991
ENST00000429063
H7C376 [Direct mapping]
E3 ubiquitin-protein ligase TRIM22
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 37 aa
4.3 kDa 		No 0
TRIM22-011
ENSP00000404204
ENST00000444844
H7C262 [Direct mapping]
E3 ubiquitin-protein ligase TRIM22
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 38 aa
4.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.