Expression of UBE2G1 in cancer - Summary - The Human Protein Atlas

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UBE2G1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	UBE2G1
Gene description	Ubiquitin-conjugating enzyme E2G 1
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA045681 , HPA050551
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045681	HPA050551

GENE INFORMATION
Gene name	UBE2G1 (HGNC Symbol)
Synonyms	UBC7, UBE2G
Description	Ubiquitin-conjugating enzyme E2G 1 (HGNC Symbol)
Entrez gene summary	The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p13.2
Chromosome location (bp)	4269259 - 4366628
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132388 (version 83.38)
Entrez gene	7326
UniProt	P62253 (UniProt - Evidence at protein level)
neXtProt	NX_P62253
Antibodypedia	UBE2G1 antibodies

PROTEIN BROWSER

UBE2G1-001	UBE2G1-002	UBE2G1-003	UBE2G1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UBE2G1-001 ENSP00000380178 ENST00000396981	P62253 [Direct mapping] Ubiquitin-conjugating enzyme E2 G1 Ubiquitin-conjugating enzyme E2 G1, N-terminally processed Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0031625 [ubiquitin protein ligase binding] GO:0044257 [cellular protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] GO:0061631 [ubiquitin conjugating enzyme activity] GO:0070062 [extracellular exosome] GO:0070534 [protein K63-linked ubiquitination] GO:0070936 [protein K48-linked ubiquitination] Show all	170 aa 19.5 kDa	No	0
UBE2G1-002 ENSP00000459691 ENST00000572484	I3L2H7 [Direct mapping] Ubiquitin-conjugating enzyme E2 G1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0061630 [ubiquitin protein ligase activity] Show all	99 aa 11.4 kDa	No	0
UBE2G1-003 ENSP00000459485 ENST00000574059		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		6 aa 0.8 kDa	No	0
UBE2G1-004 ENSP00000467502 ENST00000571953	K7EPR7 [Direct mapping] Ubiquitin-conjugating enzyme E2 G1; Ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast), isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0061630 [ubiquitin protein ligase activity] Show all	78 aa 9 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.