Expression of SEC61G in cancer - Summary - The Human Protein Atlas

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SEC61G

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SEC61G
Gene description	Sec61 translocon gamma subunit
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA053196
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), head and neck cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Head and neck cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA053196

GENE INFORMATION
Gene name	SEC61G (HGNC Symbol)
Synonyms	SSS1
Description	Sec61 translocon gamma subunit (HGNC Symbol)
Entrez gene summary	The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	p11.2
Chromosome location (bp)	54752250 - 54759974
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132432 (version 83.38)
Entrez gene	23480
UniProt	P60059 (UniProt - Evidence at protein level)
neXtProt	NX_P60059
Antibodypedia	SEC61G antibodies

PROTEIN BROWSER

SEC61G-001	SEC61G-002	SEC61G-005	SEC61G-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SEC61G-001 ENSP00000388337 ENST00000415949	P60059 [Direct mapping] Protein transport protein Sec61 subunit gamma A0A024QYZ0 [Target identity:100%; Query identity:100%] Sec61 gamma subunit, isoform CRA_a Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006412 [translation] GO:0006605 [protein targeting] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0006886 [intracellular protein transport] GO:0008565 [protein transporter activity] GO:0010467 [gene expression] GO:0015031 [protein transport] GO:0015450 [P-P-bond-hydrolysis-driven protein transmembrane transporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0036498 [IRE1-mediated unfolded protein response] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0044267 [cellular protein metabolic process] GO:0045047 [protein targeting to ER] GO:0071806 [protein transmembrane transport] Show all	68 aa 7.7 kDa	No	1
SEC61G-002 ENSP00000378906 ENST00000395535	P60059 [Direct mapping] Protein transport protein Sec61 subunit gamma A0A024QYZ0 [Target identity:100%; Query identity:100%] Sec61 gamma subunit, isoform CRA_a Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006412 [translation] GO:0006605 [protein targeting] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0006886 [intracellular protein transport] GO:0008565 [protein transporter activity] GO:0010467 [gene expression] GO:0015031 [protein transport] GO:0015450 [P-P-bond-hydrolysis-driven protein transmembrane transporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0036498 [IRE1-mediated unfolded protein response] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0044267 [cellular protein metabolic process] GO:0045047 [protein targeting to ER] GO:0071806 [protein transmembrane transport] Show all	68 aa 7.7 kDa	No	1
SEC61G-005 ENSP00000409884 ENST00000450622	P60059 [Direct mapping] Protein transport protein Sec61 subunit gamma A0A024QYZ0 [Target identity:100%; Query identity:100%] Sec61 gamma subunit, isoform CRA_a Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006412 [translation] GO:0006605 [protein targeting] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0006886 [intracellular protein transport] GO:0008565 [protein transporter activity] GO:0010467 [gene expression] GO:0015031 [protein transport] GO:0015450 [P-P-bond-hydrolysis-driven protein transmembrane transporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0036498 [IRE1-mediated unfolded protein response] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0044267 [cellular protein metabolic process] GO:0045047 [protein targeting to ER] GO:0071806 [protein transmembrane transport] Show all	68 aa 7.7 kDa	No	1
SEC61G-201 ENSP00000341538 ENST00000352861	P60059 [Direct mapping] Protein transport protein Sec61 subunit gamma A0A024QYZ0 [Target identity:100%; Query identity:100%] Sec61 gamma subunit, isoform CRA_a Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006412 [translation] GO:0006605 [protein targeting] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0006886 [intracellular protein transport] GO:0008565 [protein transporter activity] GO:0010467 [gene expression] GO:0015031 [protein transport] GO:0015450 [P-P-bond-hydrolysis-driven protein transmembrane transporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0036498 [IRE1-mediated unfolded protein response] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0044267 [cellular protein metabolic process] GO:0045047 [protein targeting to ER] GO:0071806 [protein transmembrane transport] Show all	68 aa 7.7 kDa	No	1

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