Cell atlas - XAF1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

XAF1

TISSUE

premium

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria
	Nucleus
	Rods & Rings

Human cell
	Cytosol
	Mitochondria
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	XAF1
Gene description	XIAP associated factor 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria. In addition localized to the nucleus & rods & rings.
RNA cell category	Cell line enhanced (BJ hTERT+ SV40 Large T+ RasG12V, BJ hTERT+ SV40 Large T+)
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)
Additional location	In addition localized to the Nucleus (approved), Rods & Rings (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA057302
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BJ hTERT+ SV40 Large T+ RasG12V, BJ hTERT+ SV40 Large T+) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria. In addition localized to the nucleus & rods & rings.

Main location

Mitochondria (supported)

Additional location

Nucleus (approved), Rods & Rings (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA057302	BJ	Nucleus
	HPA057302	BJ	Mitochondria	Intensity
	HPA057302	SK-MEL-30	Nucleoplasm
	HPA057302	U-2 OS	Rods & Rings

CUSTOM DATA


	Toggle channels

Thumbnail	Antibody	Cell line	Assay	Description
	HPA057302	U-2 OS	Image	U-2 OS cells were treated with Ribavirin to induce the formation of Rods & Rings. Co-localization shows that XAF1 localizes to Rods & Rings as the staining overlaps with a marker for Rods & Rings.

GENE INFORMATION
Gene name	XAF1 (HGNC Symbol)
Synonyms	BIRC4BP, HSXIAPAF1, XIAPAF1
Description	XIAP associated factor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	6755447 - 6775647
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132530 (version 83.38)
Entrez gene	54739
UniProt	Q6GPH4 (UniProt - Evidence at protein level)
neXtProt	NX_Q6GPH4
Antibodypedia	XAF1 antibodies

PROTEIN BROWSER

XAF1-001	XAF1-002	XAF1-011	XAF1-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
XAF1-001 ENSP00000354822 ENST00000361842	Q6GPH4 [Direct mapping] XIAP-associated factor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006915 [apoptotic process] GO:0008270 [zinc ion binding] GO:0019221 [cytokine-mediated signaling pathway] GO:0031333 [negative regulation of protein complex assembly] GO:0035456 [response to interferon-beta] GO:0060337 [type I interferon signaling pathway] Show all	301 aa 34.6 kDa	No	0
XAF1-002 ENSP00000341029 ENST00000346752	Q6GPH4 [Direct mapping] XIAP-associated factor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006915 [apoptotic process] GO:0008270 [zinc ion binding] GO:0019221 [cytokine-mediated signaling pathway] GO:0035456 [response to interferon-beta] GO:0060337 [type I interferon signaling pathway] Show all	282 aa 32.5 kDa	No	0
XAF1-011 ENSP00000460315 ENST00000574907	I3L3B3 [Direct mapping] XIAP-associated factor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	190 aa 20.7 kDa	No	0
XAF1-016 ENSP00000460373 ENST00000574394	I3L3D9 [Direct mapping] XIAP-associated factor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	133 aa 15.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.