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XAF1

GENERAL INFORMATION

Gene name

 XAF1

Gene description

 XIAP associated factor 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA057302
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Thyroid cancer

STAINING SUMMARY
HPA057302

GENE INFORMATION

Gene name

 XAF1 (HGNC Symbol)

Synonyms

 BIRC4BP, HSXIAPAF1, XIAPAF1

Description

 XIAP associated factor 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 6755447 - 6775647

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132530 (version 83.38)

Entrez gene

 54739

UniProt

 Q6GPH4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6GPH4

Antibodypedia

 XAF1 antibodies

PROTEIN BROWSER
XAF1-001
XAF1-002
XAF1-011
XAF1-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
XAF1-001
ENSP00000354822
ENST00000361842
Q6GPH4 [Direct mapping]
XIAP-associated factor 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0008270 [zinc ion binding]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031333 [negative regulation of protein complex assembly]
GO:0035456 [response to interferon-beta]
GO:0060337 [type I interferon signaling pathway]
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 301 aa
34.6 kDa 		No 0
XAF1-002
ENSP00000341029
ENST00000346752
Q6GPH4 [Direct mapping]
XIAP-associated factor 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0008270 [zinc ion binding]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0035456 [response to interferon-beta]
GO:0060337 [type I interferon signaling pathway]
Show all
 282 aa
32.5 kDa 		No 0
XAF1-011
ENSP00000460315
ENST00000574907
I3L3B3 [Direct mapping]
XIAP-associated factor 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 190 aa
20.7 kDa 		No 0
XAF1-016
ENSP00000460373
ENST00000574394
I3L3D9 [Direct mapping]
XIAP-associated factor 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008270 [zinc ion binding]
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 133 aa
15.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.