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PRMT7

GENERAL INFORMATION

Gene name

 PRMT7

Gene description

 Protein arginine methyltransferase 7

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA044241
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044241

GENE INFORMATION

Gene name

 PRMT7 (HGNC Symbol)

Synonyms

 FLJ10640, KIAA1933

Description

 Protein arginine methyltransferase 7 (HGNC Symbol)

Entrez gene summary

 Arginine methylation is an apparently irreversible protein modification catalyzed by arginine methyltransferases, such as PMT7, using S-adenosylmethionine (AdoMet) as the methyl donor. Arginine methylation is implicated in signal transduction, RNA transport, and RNA splicing (Miranda et al., 2004 [PubMed 15044439]).[supplied by OMIM, Mar 2008]

Chromosome

 16

Cytoband

 q22.1

Chromosome location (bp)

 68310974 - 68358563

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132600 (version 83.38)

Entrez gene

 54496

UniProt

 Q9NVM4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NVM4

Antibodypedia

 PRMT7 antibodies

PROTEIN BROWSER
PRMT7-001
PRMT7-014
PRMT7-019
PRMT7-023
PRMT7-027
PRMT7-030
PRMT7-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRMT7-001
ENSP00000343103
ENST00000339507
Q9NVM4 [Direct mapping]
Protein arginine N-methyltransferase 7
A0A024R726 [Target identity:100%; Query identity:100%]
Protein arginine methyltransferase 7, isoform CRA_a
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Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000387 [spliceosomal snRNP assembly]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006325 [chromatin organization]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0008469 [histone-arginine N-methyltransferase activity]
GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity]
GO:0016277 [[myelin basic protein]-arginine N-methyltransferase activity]
GO:0016571 [histone methylation]
GO:0018216 [peptidyl-arginine methylation]
GO:0019918 [peptidyl-arginine methylation, to symmetrical-dimethyl arginine]
GO:0019919 [peptidyl-arginine methylation, to asymmetrical-dimethyl arginine]
GO:0030154 [cell differentiation]
GO:0034969 [histone arginine methylation]
GO:0035241 [protein-arginine omega-N monomethyltransferase activity]
GO:0035242 [protein-arginine omega-N asymmetric methyltransferase activity]
GO:0035243 [protein-arginine omega-N symmetric methyltransferase activity]
GO:0035246 [peptidyl-arginine N-methylation]
GO:0035247 [peptidyl-arginine omega-N-methylation]
GO:0042393 [histone binding]
GO:0043021 [ribonucleoprotein complex binding]
GO:0043046 [DNA methylation involved in gamete generation]
GO:0043393 [regulation of protein binding]
GO:0043985 [histone H4-R3 methylation]
GO:0044020 [histone methyltransferase activity (H4-R3 specific)]
Show all
 692 aa
78.5 kDa 		No 0
PRMT7-014
ENSP00000414716
ENST00000449359
Q9NVM4 [Direct mapping]
Protein arginine N-methyltransferase 7
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000387 [spliceosomal snRNP assembly]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006325 [chromatin organization]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0008469 [histone-arginine N-methyltransferase activity]
GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity]
GO:0016277 [[myelin basic protein]-arginine N-methyltransferase activity]
GO:0016571 [histone methylation]
GO:0018216 [peptidyl-arginine methylation]
GO:0019918 [peptidyl-arginine methylation, to symmetrical-dimethyl arginine]
GO:0019919 [peptidyl-arginine methylation, to asymmetrical-dimethyl arginine]
GO:0030154 [cell differentiation]
GO:0034969 [histone arginine methylation]
GO:0035241 [protein-arginine omega-N monomethyltransferase activity]
GO:0035242 [protein-arginine omega-N asymmetric methyltransferase activity]
GO:0035243 [protein-arginine omega-N symmetric methyltransferase activity]
GO:0035246 [peptidyl-arginine N-methylation]
GO:0035247 [peptidyl-arginine omega-N-methylation]
GO:0042393 [histone binding]
GO:0043021 [ribonucleoprotein complex binding]
GO:0043046 [DNA methylation involved in gamete generation]
GO:0043393 [regulation of protein binding]
GO:0044020 [histone methyltransferase activity (H4-R3 specific)]
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 642 aa
73.2 kDa 		No 0
PRMT7-019
ENSP00000456190
ENST00000565745
H3BRD3 [Direct mapping]
Protein arginine N-methyltransferase 7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006355 [regulation of transcription, DNA-templated]
GO:0019919 [peptidyl-arginine methylation, to asymmetrical-dimethyl arginine]
GO:0034969 [histone arginine methylation]
GO:0035242 [protein-arginine omega-N asymmetric methyltransferase activity]
Show all
 72 aa
8.4 kDa 		No 0
PRMT7-023
ENSP00000454980
ENST00000566657
H3BNS2 [Direct mapping]
Protein arginine N-methyltransferase 7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006355 [regulation of transcription, DNA-templated]
GO:0019919 [peptidyl-arginine methylation, to asymmetrical-dimethyl arginine]
GO:0034969 [histone arginine methylation]
GO:0035242 [protein-arginine omega-N asymmetric methyltransferase activity]
Show all
 80 aa
9.1 kDa 		No 0
PRMT7-027
ENSP00000455538
ENST00000569571
H3BPZ8 [Direct mapping]
Protein arginine N-methyltransferase 7
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0019919 [peptidyl-arginine methylation, to asymmetrical-dimethyl arginine]
GO:0034969 [histone arginine methylation]
GO:0035242 [protein-arginine omega-N asymmetric methyltransferase activity]
Show all
 223 aa
24.8 kDa 		No 0
PRMT7-030
ENSP00000456848
ENST00000569047
H3BSS9 [Direct mapping]
Protein arginine N-methyltransferase 7
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0019919 [peptidyl-arginine methylation, to asymmetrical-dimethyl arginine]
GO:0034969 [histone arginine methylation]
GO:0035242 [protein-arginine omega-N asymmetric methyltransferase activity]
Show all
 169 aa
18.8 kDa 		No 0
PRMT7-201
ENSP00000409324
ENST00000441236
Q9NVM4 [Direct mapping]
Protein arginine N-methyltransferase 7
A0A024R726 [Target identity:100%; Query identity:100%]
Protein arginine methyltransferase 7, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000387 [spliceosomal snRNP assembly]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006325 [chromatin organization]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0008469 [histone-arginine N-methyltransferase activity]
GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity]
GO:0016277 [[myelin basic protein]-arginine N-methyltransferase activity]
GO:0016571 [histone methylation]
GO:0018216 [peptidyl-arginine methylation]
GO:0019918 [peptidyl-arginine methylation, to symmetrical-dimethyl arginine]
GO:0019919 [peptidyl-arginine methylation, to asymmetrical-dimethyl arginine]
GO:0030154 [cell differentiation]
GO:0034969 [histone arginine methylation]
GO:0035241 [protein-arginine omega-N monomethyltransferase activity]
GO:0035242 [protein-arginine omega-N asymmetric methyltransferase activity]
GO:0035243 [protein-arginine omega-N symmetric methyltransferase activity]
GO:0035246 [peptidyl-arginine N-methylation]
GO:0035247 [peptidyl-arginine omega-N-methylation]
GO:0042393 [histone binding]
GO:0043021 [ribonucleoprotein complex binding]
GO:0043046 [DNA methylation involved in gamete generation]
GO:0043393 [regulation of protein binding]
GO:0044020 [histone methyltransferase activity (H4-R3 specific)]
Show all
 692 aa
78.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.