Expression of RHBG in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	RHBG
Gene description	Rh family, B glycoprotein (gene/pseudogene)
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (liver cancer, renal cancer, urothelial cancer)
HPA (cell line):	Group enriched (CACO-2, Hep G2, RT4)
HPA (normal tissue):	Tissue enhanced (kidney, ovary)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous and cytoplasmic expression in squamous epithelial cells and in a subset of renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA048489
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (liver cancer, renal cancer, urothelial cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA048489

GENE INFORMATION
Gene name	RHBG (HGNC Symbol)
Synonyms	SLC42A2
Description	Rh family, B glycoprotein (gene/pseudogene) (HGNC Symbol)
Entrez gene summary	This gene encodes one of two non-erythroid members of the Rhesus (Rh) protein family. Non-erythroid Rh protein family members are mainly expressed in the kidney and belong to the methylammonium-ammonium permease/ammonia transporters superfamily. All Rh family proteins are predicted to be transmembrane proteins with 12 membrane spanning domains and intracytoplasmic N- and C-termini. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Chromosome	1
Cytoband	q22
Chromosome location (bp)	156369212 - 156385219
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132677 (version 83.38)
Entrez gene	57127
UniProt	Q9H310 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H310
Antibodypedia	RHBG antibodies

PROTEIN BROWSER

RHBG-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RHBG-001 ENSP00000441197 ENST00000537040	Q9H310 [Direct mapping] Ammonium transporter Rh type B Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0008519 [ammonium transmembrane transporter activity] GO:0014731 [spectrin-associated cytoskeleton] GO:0015696 [ammonium transport] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0030506 [ankyrin binding] GO:0030659 [cytoplasmic vesicle membrane] GO:0046658 [anchored component of plasma membrane] GO:0055085 [transmembrane transport] GO:0070634 [transepithelial ammonium transport] GO:0072488 [ammonium transmembrane transport] Show all	458 aa 49.5 kDa	No	>9