Expression of NES in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	NES
Gene description	Nestin
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (glioma, melanoma, testis cancer)
HPA (cell line):	Cell line enhanced (AF22, LHCN-M2, RH-30)
HPA (normal tissue):	Tissue enhanced (heart muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective expression in endothelial cells, renal glomeruli, myoepithelial cells and cardiac myocytes.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 4 antibodies. HPA007007 , HPA026111 , CAB005889 , CAB058692
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (glioma, melanoma, testis cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA007007	HPA026111	CAB005889	CAB058692

GENE INFORMATION
Gene name	NES (HGNC Symbol)
Synonyms	FLJ21841
Description	Nestin (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells. [provided by RefSeq, Sep 2011]
Chromosome	1
Cytoband	q23.1
Chromosome location (bp)	156668763 - 156677397
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132688 (version 83.38)
Entrez gene	10763
UniProt	P48681 (UniProt - Evidence at protein level)
neXtProt	NX_P48681
Antibodypedia	NES antibodies

PROTEIN BROWSER

NES-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NES-001 ENSP00000357206 ENST00000368223	P48681 [Direct mapping] Nestin Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0003674 [molecular_function] GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005882 [intermediate filament] GO:0007399 [nervous system development] GO:0007417 [central nervous system development] GO:0007420 [brain development] GO:0019215 [intermediate filament binding] GO:0030844 [positive regulation of intermediate filament depolymerization] GO:0031076 [embryonic camera-type eye development] GO:0032091 [negative regulation of protein binding] GO:0043086 [negative regulation of catalytic activity] GO:0043524 [negative regulation of neuron apoptotic process] GO:0045111 [intermediate filament cytoskeleton] GO:0048858 [cell projection morphogenesis] GO:0072089 [stem cell proliferation] GO:2000179 [positive regulation of neural precursor cell proliferation] Show all	1621 aa 177.4 kDa	No	0