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HAPLN2

GENERAL INFORMATION

Gene name

 HAPLN2

Gene description

 Hyaluronan and proteoglycan link protein 2

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct expression in processes in CNS

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA045765
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA045765

GENE INFORMATION

Gene name

 HAPLN2 (HGNC Symbol)

Synonyms

 BRAL1

Description

 Hyaluronan and proteoglycan link protein 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 q23.1

Chromosome location (bp)

 156619294 - 156625725

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132702 (version 83.38)

Entrez gene

 60484

UniProt

 Q9GZV7 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9GZV7

Antibodypedia

 HAPLN2 antibodies

PROTEIN BROWSER
HAPLN2-001
HAPLN2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HAPLN2-001
ENSP00000255039
ENST00000255039
Q9GZV7 [Direct mapping]
Hyaluronan and proteoglycan link protein 2
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001501 [skeletal system development]
GO:0005515 [protein binding]
GO:0005540 [hyaluronic acid binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0007155 [cell adhesion]
GO:0007417 [central nervous system development]
GO:0008065 [establishment of blood-nerve barrier]
GO:0085029 [extracellular matrix assembly]
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 340 aa
37.8 kDa 		Yes 0
HAPLN2-004
ENSP00000388835
ENST00000456112
Q5T3J1 [Direct mapping]
Hyaluronan and proteoglycan link protein 2
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0001501 [skeletal system development]
GO:0005515 [protein binding]
GO:0005540 [hyaluronic acid binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0007155 [cell adhesion]
GO:0007417 [central nervous system development]
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 185 aa
20.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.