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RNA cell line category: Cell line enhanced (RH-30)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.
Cell lines sorted after biological source for establishment.
Cell lines sorted after the cell line category according to Cellosaurus.
Cell lines sorted on descending RNA expression.
Cell lines sorted alphabetically.
GENE INFORMATION
Gene name
APCS (HGNC Symbol)
Synonyms
MGC88159, PTX2, SAP
Description
Amyloid P component, serum (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. [provided by RefSeq, Sep 2008]
P02743 [Direct mapping] Serum amyloid P-component Serum amyloid P-component(1-203) V9HWP0 [Target identity:100%; Query identity:100%] Amyloid P component, serum; Epididymis secretory sperm binding protein Li 92n
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Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001849 [complement component C1q binding] GO:0002674 [negative regulation of acute inflammatory response] GO:0005509 [calcium ion binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0006457 [protein folding] GO:0006953 [acute-phase response] GO:0030246 [carbohydrate binding] GO:0031012 [extracellular matrix] GO:0044267 [cellular protein metabolic process] GO:0044869 [negative regulation by host of viral exo-alpha-sialidase activity] GO:0044871 [negative regulation by host of viral glycoprotein metabolic process] GO:0045087 [innate immune response] GO:0045656 [negative regulation of monocyte differentiation] GO:0046597 [negative regulation of viral entry into host cell] GO:0046790 [virion binding] GO:0048525 [negative regulation of viral process] GO:0051082 [unfolded protein binding] GO:0051131 [chaperone-mediated protein complex assembly] GO:0061045 [negative regulation of wound healing] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] GO:1903016 [negative regulation of exo-alpha-sialidase activity] GO:1903019 [negative regulation of glycoprotein metabolic process]
