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APCS

GENERAL INFORMATION

Gene name

 APCS

Gene description

 Amyloid P component, serum

Protein class

 Disease related genes
Plasma proteins
Potential drug targets
Predicted secreted proteins
Transporters

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enhanced (RH-30)
HPA (normal tissue):Tissue enriched (liver)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct positivity in plasma.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 2 antibodies.
HPA053294 , CAB007817
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA053294
CAB007817

GENE INFORMATION

Gene name

 APCS (HGNC Symbol)

Synonyms

 MGC88159, PTX2, SAP

Description

 Amyloid P component, serum (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. [provided by RefSeq, Sep 2008]

Chromosome

 1

Cytoband

 q23.2

Chromosome location (bp)

 159587825 - 159588865

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132703 (version 83.38)

Entrez gene

 325

UniProt

 P02743 (UniProt - Evidence at protein level)

neXtProt

 NX_P02743

Antibodypedia

 APCS antibodies

PROTEIN BROWSER
APCS-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
APCS-001
ENSP00000255040
ENST00000255040
P02743 [Direct mapping]
Serum amyloid P-component Serum amyloid P-component(1-203)
V9HWP0 [Target identity:100%; Query identity:100%]
Amyloid P component, serum; Epididymis secretory sperm binding protein Li 92n
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Transporters
   Transporter channels and pores
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001849 [complement component C1q binding]
GO:0002674 [negative regulation of acute inflammatory response]
GO:0005509 [calcium ion binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0006457 [protein folding]
GO:0006953 [acute-phase response]
GO:0030246 [carbohydrate binding]
GO:0031012 [extracellular matrix]
GO:0044267 [cellular protein metabolic process]
GO:0044869 [negative regulation by host of viral exo-alpha-sialidase activity]
GO:0044871 [negative regulation by host of viral glycoprotein metabolic process]
GO:0045087 [innate immune response]
GO:0045656 [negative regulation of monocyte differentiation]
GO:0046597 [negative regulation of viral entry into host cell]
GO:0046790 [virion binding]
GO:0048525 [negative regulation of viral process]
GO:0051082 [unfolded protein binding]
GO:0051131 [chaperone-mediated protein complex assembly]
GO:0061045 [negative regulation of wound healing]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
GO:1903016 [negative regulation of exo-alpha-sialidase activity]
GO:1903019 [negative regulation of glycoprotein metabolic process]
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 223 aa
25.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.