Expression of ACY3 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ACY3
Gene description	Aminoacylase 3
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (CAPAN-2, Daudi)
HPA (normal tissue):	Tissue enhanced (duodenum, kidney, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in glandular cells of the intestinal tract and in renal proximal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA039219 , HPA048187
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA039219	HPA048187

GENE INFORMATION
Gene name	ACY3 (HGNC Symbol)
Synonyms	ACY-3, HCBP1, MGC9740
Description	Aminoacylase 3 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q13.2
Chromosome location (bp)	67642555 - 67650659
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132744 (version 83.38)
Entrez gene	91703
UniProt	Q96HD9 (UniProt - Evidence at protein level)
neXtProt	NX_Q96HD9
Antibodypedia	ACY3 antibodies

PROTEIN BROWSER

ACY3-001	ACY3-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACY3-001 ENSP00000255082 ENST00000255082	Q96HD9 [Direct mapping] N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) A0A024R5L2 [Target identity:100%; Query identity:100%] Aspartoacylase (Aminocyclase) 3, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0004046 [aminoacylase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006805 [xenobiotic metabolic process] GO:0008150 [biological_process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016324 [apical plasma membrane] GO:0016788 [hydrolase activity, acting on ester bonds] GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides] GO:0042802 [identical protein binding] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	319 aa 35.2 kDa	No	0
ACY3-002 ENSP00000434270 ENST00000529256	E9PRA7 [Direct mapping] N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016788 [hydrolase activity, acting on ester bonds] Show all	198 aa 22 kDa	No	0