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ALDH3B2

GENERAL INFORMATION

Gene name

 ALDH3B2

Gene description

 Aldehyde dehydrogenase 3 family, member B2

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (MCF7, SK-BR-3)
HPA (normal tissue):Group enriched (breast, esophagus, skin)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues including breast.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA045132
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA045132

GENE INFORMATION

Gene name

 ALDH3B2 (HGNC Symbol)

Synonyms

 ALDH8

Description

 Aldehyde dehydrogenase 3 family, member B2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the aldehyde dehydrogenase family, a group of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The gene of this particular family member is over 10 kb in length. The expression of these transcripts is restricted to the salivary gland among the human tissues examined. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q13.2

Chromosome location (bp)

 67662162 - 67681200

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132746 (version 83.38)

Entrez gene

 222

UniProt

 P48448 (UniProt - Evidence at transcript level)

neXtProt

 NX_P48448

Antibodypedia

 ALDH3B2 antibodies

PROTEIN BROWSER
ALDH3B2-001
ALDH3B2-004
ALDH3B2-007
ALDH3B2-008
ALDH3B2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALDH3B2-001
ENSP00000431595
ENST00000530069
P48448 [Direct mapping]
Aldehyde dehydrogenase family 3 member B2
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0004030 [aldehyde dehydrogenase [NAD(P)+] activity]
GO:0006066 [alcohol metabolic process]
GO:0006068 [ethanol catabolic process]
GO:0006629 [lipid metabolic process]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 385 aa
42.6 kDa 		No 2
ALDH3B2-004
ENSP00000433718
ENST00000525827
E9PJV0 [Direct mapping]
Aldehyde dehydrogenase family 3 member B2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 148 aa
16.1 kDa 		No 2
ALDH3B2-007
ENSP00000433466
ENST00000528756
E9PKY9 [Direct mapping]
Aldehyde dehydrogenase family 3 member B2
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   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 95 aa
10.4 kDa 		No 0
ALDH3B2-008
ENSP00000435476
ENST00000531248
H0YEC0 [Direct mapping]
Aldehyde dehydrogenase family 3 member B2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 128 aa
14 kDa 		No 0
ALDH3B2-201
ENSP00000255084
ENST00000349015
P48448 [Direct mapping]
Aldehyde dehydrogenase family 3 member B2
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0004030 [aldehyde dehydrogenase [NAD(P)+] activity]
GO:0006066 [alcohol metabolic process]
GO:0006068 [ethanol catabolic process]
GO:0006629 [lipid metabolic process]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 385 aa
42.6 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.