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DPH2

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GENERAL INFORMATION

Gene name

 DPH2

Gene description

 DPH2 homolog

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA045796
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus.

Main location

 Nucleus (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA045796 HEK 293 No staining    
HPA045796 Hep G2 Nucleus
HPA045796 U-2 OS Nucleus Intensity

GENE INFORMATION

Gene name

 DPH2 (HGNC Symbol)

Synonyms

 DPH2L2

Description

 DPH2 homolog (HGNC Symbol)

Entrez gene summary

 This gene is one of two human genes similar to the yeast gene dph2. The yeast gene was identified by its ability to complement a diphthamide mutant strain, and thus probably functions in diphthamide biosynthesis. Diphthamide is a post-translationally modified histidine residue present in elongation factor 2 (EF2) that is the target of diphtheria toxin ADP-ribosylation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p34.1

Chromosome location (bp)

 43970000 - 43973369

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132768 (version 83.38)

Entrez gene

 1802

UniProt

 Q9BQC3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BQC3

Antibodypedia

 DPH2 antibodies

PROTEIN BROWSER
DPH2-001
DPH2-008
DPH2-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DPH2-001
ENSP00000255108
ENST00000255108
Q9BQC3 [Direct mapping]
Diphthamide biosynthesis protein 2
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0017183 [peptidyl-diphthamide biosynthetic process from peptidyl-histidine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0090560 [2-(3-amino-3-carboxypropyl)histidine synthase activity]
Show all
 489 aa
52.1 kDa 		No 0
DPH2-008
ENSP00000432162
ENST00000459879
H0YCR5 [Direct mapping]
Diphthamide biosynthesis protein 2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0017183 [peptidyl-diphthamide biosynthetic process from peptidyl-histidine]
Show all
 262 aa
27.8 kDa 		No 0
DPH2-010
ENSP00000379981
ENST00000396758
Q9BQC3 [Direct mapping]
Diphthamide biosynthesis protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0017183 [peptidyl-diphthamide biosynthetic process from peptidyl-histidine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0090560 [2-(3-amino-3-carboxypropyl)histidine synthase activity]
Show all
 261 aa
27.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.