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DPH2

GENERAL INFORMATION

Gene name

 DPH2

Gene description

 DPH2 homolog

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA045796
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and stomach cancer (favourable).
Liver cancer p<0.001
Stomach cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA045796

GENE INFORMATION

Gene name

 DPH2 (HGNC Symbol)

Synonyms

 DPH2L2

Description

 DPH2 homolog (HGNC Symbol)

Entrez gene summary

 This gene is one of two human genes similar to the yeast gene dph2. The yeast gene was identified by its ability to complement a diphthamide mutant strain, and thus probably functions in diphthamide biosynthesis. Diphthamide is a post-translationally modified histidine residue present in elongation factor 2 (EF2) that is the target of diphtheria toxin ADP-ribosylation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p34.1

Chromosome location (bp)

 43970000 - 43973369

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132768 (version 83.38)

Entrez gene

 1802

UniProt

 Q9BQC3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BQC3

Antibodypedia

 DPH2 antibodies

PROTEIN BROWSER
DPH2-001
DPH2-008
DPH2-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DPH2-001
ENSP00000255108
ENST00000255108
Q9BQC3 [Direct mapping]
Diphthamide biosynthesis protein 2
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0017183 [peptidyl-diphthamide biosynthetic process from peptidyl-histidine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0090560 [2-(3-amino-3-carboxypropyl)histidine synthase activity]
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 489 aa
52.1 kDa 		No 0
DPH2-008
ENSP00000432162
ENST00000459879
H0YCR5 [Direct mapping]
Diphthamide biosynthesis protein 2
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0017183 [peptidyl-diphthamide biosynthetic process from peptidyl-histidine]
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 262 aa
27.8 kDa 		No 0
DPH2-010
ENSP00000379981
ENST00000396758
Q9BQC3 [Direct mapping]
Diphthamide biosynthesis protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0017183 [peptidyl-diphthamide biosynthetic process from peptidyl-histidine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0090560 [2-(3-amino-3-carboxypropyl)histidine synthase activity]
Show all
 261 aa
27.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.