Cell atlas - INADL - The Human Protein Atlas

GENERAL INFORMATION
Gene name	INADL
Gene description	InaD-like (Drosophila)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the microtubule organizing center & cell junctions. In addition localized to the cytosol.
RNA cell category	Cell line enhanced (A-431)
Protein evidence	Evidence at protein level
Main location	Localized to the Cell Junctions (supported), Microtubule organizing center (supported)
Additional location	In addition localized to the Cytosol (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA066960 , HPA069079
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (A-431) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the microtubule organizing center & cell junctions. In addition localized to the cytosol.

Main location

Cell Junctions (supported), Microtubule organizing center (supported)

Additional location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA066960	A-431	Cell Junctions
HPA066960	A-431	Microtubule organizing center
HPA066960	RT4	Microtubule organizing center
HPA066960	U-2 OS	Cell Junctions
HPA069079	A-431	Cell Junctions
		Microtubule organizing center	Spatial
		Cytosol
HPA069079	RT4	Microtubule organizing center
HPA069079	RT4	Cytosol
HPA069079	U-2 OS	Centrosome

GENE INFORMATION
Gene name	INADL (HGNC Symbol)
Synonyms	Cipp, PATJ
Description	InaD-like (Drosophila) (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p31.3
Chromosome location (bp)	61742477 - 62178675
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132849 (version 83.38)
Entrez gene	10207
UniProt	Q8NI35 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NI35
Antibodypedia	INADL antibodies

PROTEIN BROWSER

INADL-001	INADL-007	INADL-008	INADL-009	INADL-010	INADL-014	INADL-201	INADL-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
INADL-001 ENSP00000360200 ENST00000371158	Q8NI35 [Direct mapping] InaD-like protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0016324 [apical plasma membrane] GO:0034329 [cell junction assembly] GO:0035556 [intracellular signal transduction] GO:0043234 [protein complex] GO:0045177 [apical part of cell] GO:0045216 [cell-cell junction organization] GO:0048471 [perinuclear region of cytoplasm] GO:0070062 [extracellular exosome] GO:0070830 [bicellular tight junction assembly] Show all	1801 aa 196.4 kDa	No	0
INADL-007 ENSP00000489130 ENST00000465798		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	139 aa 14.9 kDa	No	0
INADL-008 ENSP00000489159 ENST00000635137		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	593 aa 63.4 kDa	No	0
INADL-009 ENSP00000489200 ENST00000494842		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	146 aa 16.2 kDa	No	0
INADL-010 ENSP00000489475 ENST00000490547		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	111 aa 12.4 kDa	No	0
INADL-014 ENSP00000307496 ENST00000307297	A0A075B6E8 [Direct mapping] InaD-like protein B4DE90 [Target identity:100%; Query identity:100%] cDNA FLJ59473, highly similar to InaD-like protein Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	452 aa 49 kDa	No	0
INADL-201 ENSP00000326199 ENST00000316485	Q8NI35 [Direct mapping] InaD-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0016324 [apical plasma membrane] GO:0034329 [cell junction assembly] GO:0035556 [intracellular signal transduction] GO:0045216 [cell-cell junction organization] GO:0048471 [perinuclear region of cytoplasm] GO:0070062 [extracellular exosome] GO:0070830 [bicellular tight junction assembly] Show all	1181 aa 130 kDa	No	0
INADL-202 ENSP00000479041 ENST00000613764	A0A087WUZ6 [Direct mapping] InaD-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1182 aa 130.1 kDa	No	0