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ALOX5AP

GENERAL INFORMATION

Gene name

 ALOX5AP

Gene description

 Arachidonate 5-lipoxygenase-activating protein

Protein class

 Disease related genes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear membrane expression in several tissues, including lymphoid tissue.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA026592
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ALOX5AP (HGNC Symbol)

Synonyms

 FLAP

Description

 Arachidonate 5-lipoxygenase-activating protein (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]

Chromosome

 13

Cytoband

 q12.3

Chromosome location (bp)

 30713478 - 30764426

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132965 (version 83.38)

Entrez gene

 241

UniProt

 P20292 (UniProt - Evidence at protein level)

neXtProt

 NX_P20292

Antibodypedia

 ALOX5AP antibodies

PROTEIN BROWSER
ALOX5AP-001
ALOX5AP-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALOX5AP-001
ENSP00000369858
ENST00000380490
P20292 [Direct mapping]
Arachidonate 5-lipoxygenase-activating protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006691 [leukotriene metabolic process]
GO:0008047 [enzyme activator activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019369 [arachidonic acid metabolic process]
GO:0019370 [leukotriene biosynthetic process]
GO:0019372 [lipoxygenase pathway]
GO:0031965 [nuclear membrane]
GO:0043085 [positive regulation of catalytic activity]
GO:0044281 [small molecule metabolic process]
GO:0047485 [protein N-terminus binding]
GO:0050544 [arachidonic acid binding]
GO:0070207 [protein homotrimerization]
GO:0071277 [cellular response to calcium ion]
GO:2001300 [lipoxin metabolic process]
Show all
 161 aa
18.2 kDa 		No 3
ALOX5AP-201
ENSP00000479870
ENST00000617770
A0A087WW23 [Direct mapping]
Arachidonate 5-lipoxygenase-activating protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002540 [leukotriene production involved in inflammatory response]
GO:0002675 [positive regulation of acute inflammatory response]
GO:0004051 [arachidonate 5-lipoxygenase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006691 [leukotriene metabolic process]
GO:0008047 [enzyme activator activity]
GO:0016021 [integral component of membrane]
GO:0019370 [leukotriene biosynthetic process]
GO:0019899 [enzyme binding]
GO:0042803 [protein homodimerization activity]
GO:0043085 [positive regulation of catalytic activity]
GO:0046982 [protein heterodimerization activity]
GO:0055114 [oxidation-reduction process]
GO:0070207 [protein homotrimerization]
Show all
 218 aa
24.2 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.