Fields »
ABOUT
HELP
BLOG
DSTYK

GENERAL INFORMATION

Gene name

 DSTYK

Gene description

 Dual serine/threonine and tyrosine protein kinase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General granular cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA044140
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable).
Urothelial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044140

GENE INFORMATION

Gene name

 DSTYK (HGNC Symbol)

Synonyms

 DustyPK, KIAA0472, RIP5, RIPK5

Description

 Dual serine/threonine and tyrosine protein kinase (HGNC Symbol)

Entrez gene summary

 This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. It is thought to function as a regulator of cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Chromosome

 1

Cytoband

 q32.1

Chromosome location (bp)

 205142505 - 205211566

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000133059 (version 83.38)

Entrez gene

 25778

UniProt

 Q6XUX3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6XUX3

Antibodypedia

 DSTYK antibodies

PROTEIN BROWSER
DSTYK-001
DSTYK-002
DSTYK-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DSTYK-001
ENSP00000356130
ENST00000367162
Q6XUX3 [Direct mapping]
Dual serine/threonine and tyrosine protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030054 [cell junction]
GO:0033674 [positive regulation of kinase activity]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045743 [positive regulation of fibroblast growth factor receptor signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
Show all
 929 aa
105.2 kDa 		No 0
DSTYK-002
ENSP00000356129
ENST00000367161
Q6XUX3 [Direct mapping]
Dual serine/threonine and tyrosine protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030054 [cell junction]
GO:0033674 [positive regulation of kinase activity]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045743 [positive regulation of fibroblast growth factor receptor signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
Show all
 884 aa
100 kDa 		No 0
DSTYK-201
ENSP00000478016
ENST00000615388
Q6XUX3 [Direct mapping]
Dual serine/threonine and tyrosine protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030054 [cell junction]
GO:0033674 [positive regulation of kinase activity]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045743 [positive regulation of fibroblast growth factor receptor signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
Show all
 179 aa
20.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.