Expression of CHIT1 in cancer - Summary - The Human Protein Atlas

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CHIT1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CHIT1
Gene description	Chitinase 1 (chitotriosidase)
Protein class	Candidate cardiovascular disease genes Enzymes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (testis cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Group enriched (bone marrow, breast, cervix, uterine, lung, lymph node)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in subset of cells in spleen, bone marrow and lymph node.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA010575
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA010575

GENE INFORMATION
Gene name	CHIT1 (HGNC Symbol)
Synonyms	CHI3, CHIT
Description	Chitinase 1 (chitotriosidase) (HGNC Symbol)
Entrez gene summary	Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012]
Chromosome	1
Cytoband	q32.1
Chromosome location (bp)	203212827 - 203273641
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133063 (version 83.38)
Entrez gene	1118
UniProt	Q13231 (UniProt - Evidence at protein level)
neXtProt	NX_Q13231
Antibodypedia	CHIT1 antibodies

PROTEIN BROWSER

CHIT1-001	CHIT1-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHIT1-001 ENSP00000356198 ENST00000367229	Q13231 [Direct mapping] Chitotriosidase-1 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000272 [polysaccharide catabolic process] GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005764 [lysosome] GO:0005975 [carbohydrate metabolic process] GO:0006030 [chitin metabolic process] GO:0006032 [chitin catabolic process] GO:0006955 [immune response] GO:0008061 [chitin binding] GO:0008843 [endochitinase activity] GO:0009617 [response to bacterium] Show all	466 aa 51.7 kDa	Yes	0
CHIT1-007 ENSP00000255427 ENST00000255427	Q13231 [Direct mapping] Chitotriosidase-1 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000272 [polysaccharide catabolic process] GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005764 [lysosome] GO:0005975 [carbohydrate metabolic process] GO:0006030 [chitin metabolic process] GO:0006032 [chitin catabolic process] GO:0006955 [immune response] GO:0008061 [chitin binding] GO:0008843 [endochitinase activity] GO:0009617 [response to bacterium] Show all	447 aa 49.6 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.