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CHIT1

GENERAL INFORMATION

Gene name

 CHIT1

Gene description

 Chitinase 1 (chitotriosidase)

Protein class

 Candidate cardiovascular disease genes
Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (bone marrow, breast, cervix, uterine, lung, lymph node)
GTEx:Group enriched (adipose tissue, breast, endometrium, lung, spleen)
FANTOM5:Group enriched (adipose tissue, lymph node)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in subset of cells in spleen, bone marrow and lymph node.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA010575
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (bone marrow, breast, cervix, uterine, lung, lymph node)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adipose tissue, breast, endometrium, lung, spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adipose tissue, lymph node)

GENE INFORMATION

Gene name

 CHIT1 (HGNC Symbol)

Synonyms

 CHI3, CHIT

Description

 Chitinase 1 (chitotriosidase) (HGNC Symbol)

Entrez gene summary

 Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012]

Chromosome

 1

Cytoband

 q32.1

Chromosome location (bp)

 203212827 - 203273641

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000133063 (version 83.38)

Entrez gene

 1118

UniProt

 Q13231 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13231

Antibodypedia

 CHIT1 antibodies

PROTEIN BROWSER
CHIT1-001
CHIT1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHIT1-001
ENSP00000356198
ENST00000367229
Q13231 [Direct mapping]
Chitotriosidase-1
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Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000272 [polysaccharide catabolic process]
GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds]
GO:0004568 [chitinase activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005764 [lysosome]
GO:0005975 [carbohydrate metabolic process]
GO:0006030 [chitin metabolic process]
GO:0006032 [chitin catabolic process]
GO:0006955 [immune response]
GO:0008061 [chitin binding]
GO:0008843 [endochitinase activity]
GO:0009617 [response to bacterium]
Show all
 466 aa
51.7 kDa 		Yes 0
CHIT1-007
ENSP00000255427
ENST00000255427
Q13231 [Direct mapping]
Chitotriosidase-1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000272 [polysaccharide catabolic process]
GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds]
GO:0004568 [chitinase activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005764 [lysosome]
GO:0005975 [carbohydrate metabolic process]
GO:0006030 [chitin metabolic process]
GO:0006032 [chitin catabolic process]
GO:0006955 [immune response]
GO:0008061 [chitin binding]
GO:0008843 [endochitinase activity]
GO:0009617 [response to bacterium]
Show all
 447 aa
49.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.