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Gliomas, melanomas and cases of lymphomas, breast and female genital cancers showed moderate to strong cytoplasmic immunoreactivity. Colorectal and testicular cancers were moderately positive in a few cases. Remaining cancers were in general weakly stained or negative.
A majority of gliomas, and carcinoids as well as several breast, lung and gastric cancers displayed moderate to strong immunoreactivity. A majority of the remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
DCLK1 (HGNC Symbol)
Synonyms
DCAMKL1, DCDC3A, DCLK, KIAA0369
Description
Doublecortin-like kinase 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]