Expression of DCLK1 in cancer - Summary - The Human Protein Atlas

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DCLK1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DCLK1
Gene description	Doublecortin-like kinase 1
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (glioma)
HPA (cell line):	Cell line enhanced (ASC TERT1, NTERA-2)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in the CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA015655 , CAB012405
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA015655	CAB012405

GENE INFORMATION
Gene name	DCLK1 (HGNC Symbol)
Synonyms	DCAMKL1, DCDC3A, DCLK, KIAA0369
Description	Doublecortin-like kinase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]
Chromosome	13
Cytoband	q13.3
Chromosome location (bp)	35768652 - 36131306
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133083 (version 83.38)
Entrez gene	9201
UniProt	O15075 (UniProt - Evidence at protein level)
neXtProt	NX_O15075
Antibodypedia	DCLK1 antibodies

PROTEIN BROWSER

DCLK1-001	DCLK1-006	DCLK1-010	DCLK1-011	DCLK1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DCLK1-001 ENSP00000369222 ENST00000379892	Q5VZY9 [Direct mapping] Serine/threonine-protein kinase DCLK1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0035556 [intracellular signal transduction] Show all	363 aa 40.5 kDa	No	0
DCLK1-006 ENSP00000255448 ENST00000255448	O15075 [Direct mapping] Serine/threonine-protein kinase DCLK1 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001764 [neuron migration] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005057 [receptor signaling protein activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007399 [nervous system development] GO:0007409 [axonogenesis] GO:0007417 [central nervous system development] GO:0007420 [brain development] GO:0009615 [response to virus] GO:0016197 [endosomal transport] GO:0021952 [central nervous system projection neuron axonogenesis] GO:0030900 [forebrain development] GO:0035556 [intracellular signal transduction] GO:0048675 [axon extension] GO:0048813 [dendrite morphogenesis] GO:0097481 [neuronal postsynaptic density] Show all	729 aa 81.1 kDa	No	1
DCLK1-010 ENSP00000353846 ENST00000360631	O15075 [Direct mapping] Serine/threonine-protein kinase DCLK1 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005057 [receptor signaling protein activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007399 [nervous system development] GO:0007417 [central nervous system development] GO:0009615 [response to virus] GO:0016197 [endosomal transport] GO:0035556 [intracellular signal transduction] Show all	740 aa 82.2 kDa	No	1
DCLK1-011 ENSP00000369223 ENST00000379893	O15075 [Direct mapping] Serine/threonine-protein kinase DCLK1 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005057 [receptor signaling protein activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007399 [nervous system development] GO:0007417 [central nervous system development] GO:0009615 [response to virus] GO:0016197 [endosomal transport] GO:0035556 [intracellular signal transduction] Show all	433 aa 47.7 kDa	No	1
DCLK1-201 ENSP00000484452 ENST00000615680	O15075 [Direct mapping] Serine/threonine-protein kinase DCLK1 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005057 [receptor signaling protein activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007399 [nervous system development] GO:0007417 [central nervous system development] GO:0009615 [response to virus] GO:0016197 [endosomal transport] GO:0035556 [intracellular signal transduction] Show all	422 aa 46.6 kDa	No	1

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