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DCLK1

GENERAL INFORMATION

Gene name

 DCLK1

Gene description

 Doublecortin-like kinase 1

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Mixed
FANTOM5:Tissue enhanced (brain, hippocampus)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in the CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA015655 , CAB012405
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (brain, hippocampus)

GENE INFORMATION

Gene name

 DCLK1 (HGNC Symbol)

Synonyms

 DCAMKL1, DCDC3A, DCLK, KIAA0369

Description

 Doublecortin-like kinase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]

Chromosome

 13

Cytoband

 q13.3

Chromosome location (bp)

 35768652 - 36131306

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000133083 (version 83.38)

Entrez gene

 9201

UniProt

 O15075 (UniProt - Evidence at protein level)

neXtProt

 NX_O15075

Antibodypedia

 DCLK1 antibodies

PROTEIN BROWSER
DCLK1-001
DCLK1-006
DCLK1-010
DCLK1-011
DCLK1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DCLK1-001
ENSP00000369222
ENST00000379892
Q5VZY9 [Direct mapping]
Serine/threonine-protein kinase DCLK1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0035556 [intracellular signal transduction]
Show all
 363 aa
40.5 kDa 		No 0
DCLK1-006
ENSP00000255448
ENST00000255448
O15075 [Direct mapping]
Serine/threonine-protein kinase DCLK1
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001764 [neuron migration]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005057 [receptor signaling protein activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007399 [nervous system development]
GO:0007409 [axonogenesis]
GO:0007417 [central nervous system development]
GO:0007420 [brain development]
GO:0009615 [response to virus]
GO:0016197 [endosomal transport]
GO:0021952 [central nervous system projection neuron axonogenesis]
GO:0030900 [forebrain development]
GO:0035556 [intracellular signal transduction]
GO:0048675 [axon extension]
GO:0048813 [dendrite morphogenesis]
GO:0097481 [neuronal postsynaptic density]
Show all
 729 aa
81.1 kDa 		No 1
DCLK1-010
ENSP00000353846
ENST00000360631
O15075 [Direct mapping]
Serine/threonine-protein kinase DCLK1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005057 [receptor signaling protein activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007399 [nervous system development]
GO:0007417 [central nervous system development]
GO:0009615 [response to virus]
GO:0016197 [endosomal transport]
GO:0035556 [intracellular signal transduction]
Show all
 740 aa
82.2 kDa 		No 1
DCLK1-011
ENSP00000369223
ENST00000379893
O15075 [Direct mapping]
Serine/threonine-protein kinase DCLK1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005057 [receptor signaling protein activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007399 [nervous system development]
GO:0007417 [central nervous system development]
GO:0009615 [response to virus]
GO:0016197 [endosomal transport]
GO:0035556 [intracellular signal transduction]
Show all
 433 aa
47.7 kDa 		No 1
DCLK1-201
ENSP00000484452
ENST00000615680
O15075 [Direct mapping]
Serine/threonine-protein kinase DCLK1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005057 [receptor signaling protein activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007399 [nervous system development]
GO:0007417 [central nervous system development]
GO:0009615 [response to virus]
GO:0016197 [endosomal transport]
GO:0035556 [intracellular signal transduction]
Show all
 422 aa
46.6 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.