Cell atlas - RXFP2 - The Human Protein Atlas

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RXFP2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	RXFP2
Gene description	Relaxin/insulin-like family peptide receptor 2
Protein class	Disease related genes G-protein coupled receptors Potential drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Not detected
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	RXFP2 (HGNC Symbol)
Synonyms	GPR106, GREAT, INSL3R, LGR8, RXFPR2
Description	Relaxin/insulin-like family peptide receptor 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Chromosome	13
Cytoband	q13.1
Chromosome location (bp)	31739542 - 31803388
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133105 (version 83.38)
Entrez gene	122042
UniProt	Q8WXD0 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WXD0
Antibodypedia	RXFP2 antibodies

PROTEIN BROWSER

RXFP2-001	RXFP2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RXFP2-001 ENSP00000298386 ENST00000298386	Q8WXD0 [Direct mapping] Relaxin receptor 2 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0001556 [oocyte maturation] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] GO:0008285 [negative regulation of cell proliferation] GO:0008584 [male gonad development] GO:0016021 [integral component of membrane] GO:0016500 [protein-hormone receptor activity] GO:0017046 [peptide hormone binding] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0043066 [negative regulation of apoptotic process] Show all	754 aa 86.5 kDa	No	8
RXFP2-201 ENSP00000369670 ENST00000380314	Q8WXD0 [Direct mapping] Relaxin receptor 2 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	730 aa 83.7 kDa	No	8

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.