Expression of RXFP2 in cancer - Summary - The Human Protein Atlas

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RXFP2

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	RXFP2
Gene description	Relaxin/insulin-like family peptide receptor 2
Protein class	Disease related genes G-protein coupled receptors Potential drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Not detected

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	RXFP2 (HGNC Symbol)
Synonyms	GPR106, GREAT, INSL3R, LGR8, RXFPR2
Description	Relaxin/insulin-like family peptide receptor 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Chromosome	13
Cytoband	q13.1
Chromosome location (bp)	31739542 - 31803388
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133105 (version 83.38)
Entrez gene	122042
UniProt	Q8WXD0 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WXD0
Antibodypedia	RXFP2 antibodies

PROTEIN BROWSER

RXFP2-001	RXFP2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RXFP2-001 ENSP00000298386 ENST00000298386	Q8WXD0 [Direct mapping] Relaxin receptor 2 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0001556 [oocyte maturation] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] GO:0008285 [negative regulation of cell proliferation] GO:0008584 [male gonad development] GO:0016021 [integral component of membrane] GO:0016500 [protein-hormone receptor activity] GO:0017046 [peptide hormone binding] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0043066 [negative regulation of apoptotic process] Show all	754 aa 86.5 kDa	No	8
RXFP2-201 ENSP00000369670 ENST00000380314	Q8WXD0 [Direct mapping] Relaxin receptor 2 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	730 aa 83.7 kDa	No	8

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.