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TRPC4

GENERAL INFORMATION

Gene name

 TRPC4

Gene description

 Transient receptor potential cation channel, subfamily C, member 4

Protein class

 Plasma proteins
Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (AF22, BJ, BJ hTERT+ SV40 Large T+, U-2197)
HPA (normal tissue):Tissue enhanced (endometrium, seminal vesicle, smooth muscle)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 TRPC4 (HGNC Symbol)

Synonyms

 HTRP4, TRP4

Description

 Transient receptor potential cation channel, subfamily C, member 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

Chromosome

 13

Cytoband

 q13.3

Chromosome location (bp)

 37636636 - 37870425

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000133107 (version 83.38)

Entrez gene

 7223

UniProt

 Q9UBN4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UBN4

Antibodypedia

 TRPC4 antibodies

PROTEIN BROWSER
TRPC4-001
TRPC4-002
TRPC4-003
TRPC4-004
TRPC4-006
TRPC4-008
TRPC4-201
TRPC4-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRPC4-001
ENSP00000369027
ENST00000379705
Q9UBN4 [Direct mapping]
Short transient receptor potential channel 4
Show all
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Plasma proteins
Show all
GO:0005216 [ion channel activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006828 [manganese ion transport]
GO:0007411 [axon guidance]
GO:0008013 [beta-catenin binding]
GO:0009986 [cell surface]
GO:0015279 [store-operated calcium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0030863 [cortical cytoskeleton]
GO:0034220 [ion transmembrane transport]
GO:0034704 [calcium channel complex]
GO:0045296 [cadherin binding]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0070679 [inositol 1,4,5 trisphosphate binding]
Show all
 977 aa
112.1 kDa 		No 8
TRPC4-002
ENSP00000348025
ENST00000355779
Q9UBN4 [Direct mapping]
Short transient receptor potential channel 4
Show all
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Plasma proteins
Show all
GO:0005216 [ion channel activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006828 [manganese ion transport]
GO:0007411 [axon guidance]
GO:0008013 [beta-catenin binding]
GO:0009986 [cell surface]
GO:0015279 [store-operated calcium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0030863 [cortical cytoskeleton]
GO:0034220 [ion transmembrane transport]
GO:0034704 [calcium channel complex]
GO:0045296 [cadherin binding]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0070679 [inositol 1,4,5 trisphosphate binding]
Show all
 836 aa
96.4 kDa 		No 8
TRPC4-003
ENSP00000351264
ENST00000358477
Q9UBN4 [Direct mapping]
Short transient receptor potential channel 4
Show all
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Plasma proteins
Show all
GO:0005216 [ion channel activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006828 [manganese ion transport]
GO:0007411 [axon guidance]
GO:0008013 [beta-catenin binding]
GO:0009986 [cell surface]
GO:0015279 [store-operated calcium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0030863 [cortical cytoskeleton]
GO:0034220 [ion transmembrane transport]
GO:0034704 [calcium channel complex]
GO:0045296 [cadherin binding]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0070679 [inositol 1,4,5 trisphosphate binding]
Show all
 893 aa
102.6 kDa 		No 8
TRPC4-004
ENSP00000368995
ENST00000379673
Q9UBN4 [Direct mapping]
Short transient receptor potential channel 4
Show all
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Plasma proteins
Show all
GO:0005216 [ion channel activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006828 [manganese ion transport]
GO:0007411 [axon guidance]
GO:0008013 [beta-catenin binding]
GO:0009986 [cell surface]
GO:0015279 [store-operated calcium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0030863 [cortical cytoskeleton]
GO:0034220 [ion transmembrane transport]
GO:0034704 [calcium channel complex]
GO:0045296 [cadherin binding]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0070679 [inositol 1,4,5 trisphosphate binding]
Show all
 828 aa
94.9 kDa 		No 8
TRPC4-006
ENSP00000369001
ENST00000379679
Q9UBN4 [Direct mapping]
Short transient receptor potential channel 4
Show all
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Plasma proteins
Show all
GO:0005216 [ion channel activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006828 [manganese ion transport]
GO:0007411 [axon guidance]
GO:0008013 [beta-catenin binding]
GO:0009986 [cell surface]
GO:0015279 [store-operated calcium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0030863 [cortical cytoskeleton]
GO:0034220 [ion transmembrane transport]
GO:0034704 [calcium channel complex]
GO:0045296 [cadherin binding]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0070679 [inositol 1,4,5 trisphosphate binding]
Show all
 804 aa
92.2 kDa 		No 8
TRPC4-008
ENSP00000486109
ENST00000625583
Q9UBN4 [Direct mapping]
Short transient receptor potential channel 4
Show all
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Plasma proteins
Show all
GO:0005216 [ion channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005901 [caveola]
GO:0005911 [cell-cell junction]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006828 [manganese ion transport]
GO:0007411 [axon guidance]
GO:0008013 [beta-catenin binding]
GO:0009986 [cell surface]
GO:0014051 [gamma-aminobutyric acid secretion]
GO:0015279 [store-operated calcium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0030863 [cortical cytoskeleton]
GO:0034220 [ion transmembrane transport]
GO:0034704 [calcium channel complex]
GO:0043234 [protein complex]
GO:0045121 [membrane raft]
GO:0045296 [cadherin binding]
GO:0048709 [oligodendrocyte differentiation]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0051924 [regulation of calcium ion transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0070679 [inositol 1,4,5 trisphosphate binding]
Show all
 982 aa
112.7 kDa 		No 8
TRPC4-201
ENSP00000342580
ENST00000338947
Q9UBN4 [Direct mapping]
Short transient receptor potential channel 4
Show all
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Plasma proteins
Show all
GO:0005216 [ion channel activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006828 [manganese ion transport]
GO:0007411 [axon guidance]
GO:0008013 [beta-catenin binding]
GO:0009986 [cell surface]
GO:0015279 [store-operated calcium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0030863 [cortical cytoskeleton]
GO:0034220 [ion transmembrane transport]
GO:0034704 [calcium channel complex]
GO:0045296 [cadherin binding]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0070679 [inositol 1,4,5 trisphosphate binding]
Show all
 804 aa
92.2 kDa 		No 8
TRPC4-202
ENSP00000410133
ENST00000426868
Q3MHB9 [Direct mapping]
Short transient receptor potential channel 4; TRPC4 protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006828 [manganese ion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0070679 [inositol 1,4,5 trisphosphate binding]
Show all
 460 aa
53.1 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.