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RFC3

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GENERAL INFORMATION

Gene name

 RFC3

Gene description

 Replication factor C (activator 1) 3, 38kDa

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm & vesicles.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported), Vesicles (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA030149
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm & vesicles.

Main location

 Nucleoplasm (supported), Vesicles (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA030149 A-431 Nucleoplasm Spatial
Vesicles Spatial
HPA030149 U-2 OS Nucleoplasm
Vesicles
Cytosol
HPA030149 U-251 MG Nucleoplasm Spatial
Vesicles Spatial

GENE INFORMATION

Gene name

 RFC3 (HGNC Symbol)

Synonyms

 MGC5276, RFC38

Description

 Replication factor C (activator 1) 3, 38kDa (HGNC Symbol)

Entrez gene summary

 The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

 13

Cytoband

 q13.2

Chromosome location (bp)

 33818049 - 33966558

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000133119 (version 83.38)

Entrez gene

 5983

UniProt

 P40938 (UniProt - Evidence at protein level)

neXtProt

 NX_P40938

Antibodypedia

 RFC3 antibodies

PROTEIN BROWSER
RFC3-001
RFC3-002
RFC3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RFC3-001
ENSP00000369411
ENST00000380071
P40938 [Direct mapping]
Replication factor C subunit 3
A0A024RDQ8 [Target identity:100%; Query identity:100%]
Replication factor C (Activator 1) 3, 38kDa, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000722 [telomere maintenance via recombination]
GO:0000723 [telomere maintenance]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000731 [DNA synthesis involved in DNA repair]
GO:0003677 [DNA binding]
GO:0003689 [DNA clamp loader activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005663 [DNA replication factor C complex]
GO:0006260 [DNA replication]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006297 [nucleotide-excision repair, DNA gap filling]
GO:0006302 [double-strand break repair]
GO:0016887 [ATPase activity]
GO:0019985 [translesion synthesis]
GO:0032201 [telomere maintenance via semi-conservative replication]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0042276 [error-prone translesion synthesis]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0046683 [response to organophosphorus]
GO:0070911 [global genome nucleotide-excision repair]
GO:0070987 [error-free translesion synthesis]
Show all
 356 aa
40.6 kDa 		No 0
RFC3-002
ENSP00000484747
ENST00000616236
A0A087X270 [Direct mapping]
Replication factor C subunit 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0006260 [DNA replication]
Show all
 103 aa
11.9 kDa 		No 0
RFC3-201
ENSP00000401001
ENST00000434425
P40938 [Direct mapping]
Replication factor C subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000722 [telomere maintenance via recombination]
GO:0000723 [telomere maintenance]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000731 [DNA synthesis involved in DNA repair]
GO:0003677 [DNA binding]
GO:0003689 [DNA clamp loader activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005663 [DNA replication factor C complex]
GO:0006260 [DNA replication]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006297 [nucleotide-excision repair, DNA gap filling]
GO:0006302 [double-strand break repair]
GO:0016887 [ATPase activity]
GO:0019985 [translesion synthesis]
GO:0032201 [telomere maintenance via semi-conservative replication]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0042276 [error-prone translesion synthesis]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0046683 [response to organophosphorus]
GO:0070911 [global genome nucleotide-excision repair]
GO:0070987 [error-free translesion synthesis]
Show all
 305 aa
34.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.