Fields »
ABOUT
HELP
BLOG
RFC3

GENERAL INFORMATION

Gene name

 RFC3

Gene description

 Replication factor C (activator 1) 3, 38kDa

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear och cytoplasmic expression at variable levels in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA030149
SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA030149

GENE INFORMATION

Gene name

 RFC3 (HGNC Symbol)

Synonyms

 MGC5276, RFC38

Description

 Replication factor C (activator 1) 3, 38kDa (HGNC Symbol)

Entrez gene summary

 The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

 13

Cytoband

 q13.2

Chromosome location (bp)

 33818049 - 33966558

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000133119 (version 83.38)

Entrez gene

 5983

UniProt

 P40938 (UniProt - Evidence at protein level)

neXtProt

 NX_P40938

Antibodypedia

 RFC3 antibodies

PROTEIN BROWSER
RFC3-001
RFC3-002
RFC3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RFC3-001
ENSP00000369411
ENST00000380071
P40938 [Direct mapping]
Replication factor C subunit 3
A0A024RDQ8 [Target identity:100%; Query identity:100%]
Replication factor C (Activator 1) 3, 38kDa, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000722 [telomere maintenance via recombination]
GO:0000723 [telomere maintenance]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000731 [DNA synthesis involved in DNA repair]
GO:0003677 [DNA binding]
GO:0003689 [DNA clamp loader activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005663 [DNA replication factor C complex]
GO:0006260 [DNA replication]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006297 [nucleotide-excision repair, DNA gap filling]
GO:0006302 [double-strand break repair]
GO:0016887 [ATPase activity]
GO:0019985 [translesion synthesis]
GO:0032201 [telomere maintenance via semi-conservative replication]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0042276 [error-prone translesion synthesis]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0046683 [response to organophosphorus]
GO:0070911 [global genome nucleotide-excision repair]
GO:0070987 [error-free translesion synthesis]
Show all
 356 aa
40.6 kDa 		No 0
RFC3-002
ENSP00000484747
ENST00000616236
A0A087X270 [Direct mapping]
Replication factor C subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0006260 [DNA replication]
Show all
 103 aa
11.9 kDa 		No 0
RFC3-201
ENSP00000401001
ENST00000434425
P40938 [Direct mapping]
Replication factor C subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000722 [telomere maintenance via recombination]
GO:0000723 [telomere maintenance]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000731 [DNA synthesis involved in DNA repair]
GO:0003677 [DNA binding]
GO:0003689 [DNA clamp loader activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005663 [DNA replication factor C complex]
GO:0006260 [DNA replication]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006297 [nucleotide-excision repair, DNA gap filling]
GO:0006302 [double-strand break repair]
GO:0016887 [ATPase activity]
GO:0019985 [translesion synthesis]
GO:0032201 [telomere maintenance via semi-conservative replication]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0042276 [error-prone translesion synthesis]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0046683 [response to organophosphorus]
GO:0070911 [global genome nucleotide-excision repair]
GO:0070987 [error-free translesion synthesis]
Show all
 305 aa
34.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.