Expression of MORC4 in cancer - Summary - The Human Protein Atlas

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MORC4

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MORC4
Gene description	MORC family CW-type zinc finger 4
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression, most abundant in placenta and testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA000395 , HPA015547
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (unfavourable).
Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA000395	HPA015547

GENE INFORMATION
Gene name	MORC4 (HGNC Symbol)
Synonyms	FLJ11565, ZCW4, ZCWCC2
Description	MORC family CW-type zinc finger 4 (HGNC Symbol)
Entrez gene summary	In human, the four current members of the microrchidia (morc) gene family share an N-terminal ATPase-like ATP-binding region and a CW four-cysteine zinc-finger motif. The protein encoded by this gene also has a nuclear matrix binding domain and a two-stranded coiled-coil motif near its C-terminus. This gene is widely expressed at low levels in normal tissues and has elevated expression in placenta and testis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010]
Chromosome	X
Cytoband	q22.3
Chromosome location (bp)	106813871 - 107000244
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133131 (version 83.38)
Entrez gene	79710
UniProt	Q8TE76 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TE76
Antibodypedia	MORC4 antibodies

PROTEIN BROWSER

MORC4-001	MORC4-003	MORC4-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MORC4-001 ENSP00000347821 ENST00000355610	Q8TE76 [Direct mapping] MORC family CW-type zinc finger protein 4 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0008270 [zinc ion binding] Show all	937 aa 106.3 kDa	No	0
MORC4-003 ENSP00000255495 ENST00000255495	Q8TE76 [Direct mapping] MORC family CW-type zinc finger protein 4 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0008270 [zinc ion binding] Show all	900 aa 101.9 kDa	No	0
MORC4-004 ENSP00000474750 ENST00000604604	S4R3U3 [Direct mapping] MORC family CW-type zinc finger protein 4 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		38 aa 4.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.