Tissue expression of MYO18B - Summary - The Human Protein Atlas

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MYO18B

TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	MYO18B
Gene description	Myosin XVIIIB
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (heart muscle, skeletal muscle)
GTEx:	Group enriched (heart muscle, skeletal muscle)
FANTOM5:	Group enriched (heart muscle, skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA000953
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (heart muscle, skeletal muscle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (heart muscle, skeletal muscle)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (heart muscle, skeletal muscle)

GENE INFORMATION
Gene name	MYO18B (HGNC Symbol)
Synonyms	BK125H2.1
Description	Myosin XVIIIB (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q12.1
Chromosome location (bp)	25742144 - 26031041
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133454 (version 83.38)
Entrez gene	84700
UniProt
neXtProt
Antibodypedia	MYO18B antibodies

PROTEIN BROWSER

MYO18B-001	MYO18B-003	MYO18B-006	MYO18B-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MYO18B-001 ENSP00000334563 ENST00000335473	A0A075B6F5 [Direct mapping] Unconventional myosin-XVIIIb Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001570 [vasculogenesis] GO:0001701 [in utero embryonic development] GO:0003774 [motor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0008152 [metabolic process] GO:0016459 [myosin complex] GO:0030018 [Z disc] GO:0031941 [filamentous actin] GO:0048739 [cardiac muscle fiber development] Show all	2567 aa 285.2 kDa	No	0
MYO18B-003 ENSP00000441229 ENST00000536101	A0A075B6F5 [Direct mapping] Unconventional myosin-XVIIIb Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003774 [motor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0008152 [metabolic process] GO:0016459 [myosin complex] Show all	2567 aa 285.2 kDa	No	0
MYO18B-006 ENSP00000386096 ENST00000407587	F5GXR6 [Direct mapping] Unconventional myosin-XVIIIb Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003774 [motor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0008152 [metabolic process] GO:0016459 [myosin complex] Show all	2568 aa 285.3 kDa	No	0
MYO18B-007 ENSP00000444262 ENST00000543971	H0YGQ4 [Direct mapping] Unconventional myosin-XVIIIb Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		517 aa 56.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.