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This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell differentiation. This locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. [provided by RefSeq, Oct 2008]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014)
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GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006479 [protein methylation] GO:0006979 [response to oxidative stress] GO:0007283 [spermatogenesis] GO:0008285 [negative regulation of cell proliferation] GO:0016477 [cell migration] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0030308 [negative regulation of cell growth] GO:0043434 [response to peptide hormone] GO:0045603 [positive regulation of endothelial cell differentiation] GO:0045663 [positive regulation of myoblast differentiation] GO:0045766 [positive regulation of angiogenesis] GO:2000271 [positive regulation of fibroblast apoptotic process]
