Cell atlas - CA1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CA1
Gene description	Carbonic anhydrase I
Protein class	Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	18
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HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enriched (HEL)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (HEL) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	CA1 (HGNC Symbol)
Synonyms	Car1
Description	Carbonic anhydrase I (HGNC Symbol)
Entrez gene summary	Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This CA1 gene is closely linked to the CA2 and CA3 genes on chromosome 8. It encodes a cytosolic protein that is found at the highest level in erythrocytes. Allelic variants of this gene have been described in some populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Chromosome	8
Cytoband	q21.2
Chromosome location (bp)	85327608 - 85379014
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133742 (version 83.38)
Entrez gene	759
UniProt	P00915 (UniProt - Evidence at protein level)
neXtProt	NX_P00915
Antibodypedia	CA1 antibodies

PROTEIN BROWSER

CA1-001	CA1-003	CA1-004	CA1-005	CA1-006	CA1-007	CA1-010	CA1-011	CA1-013	CA1-014	CA1-015	CA1-019	CA1-020	CA1-021	CA1-022	CA1-201	CA1-202	CA1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CA1-001 ENSP00000430656 ENST00000523953	P00915 [Direct mapping] Carbonic anhydrase 1 V9HWE3 [Target identity:100%; Query identity:100%] Carbonic anhydrase I, isoform CRA_a; Epididymis secretory protein Li 11 Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0004064 [arylesterase activity] GO:0004089 [carbonate dehydratase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] GO:0015701 [bicarbonate transport] GO:0016836 [hydro-lyase activity] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	261 aa 28.9 kDa	No	0
CA1-003 ENSP00000429798 ENST00000523022	P00915 [Direct mapping] Carbonic anhydrase 1 V9HWE3 [Target identity:100%; Query identity:100%] Carbonic anhydrase I, isoform CRA_a; Epididymis secretory protein Li 11 Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004064 [arylesterase activity] GO:0004089 [carbonate dehydratase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] GO:0015701 [bicarbonate transport] GO:0016836 [hydro-lyase activity] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	261 aa 28.9 kDa	No	0
CA1-004 ENSP00000430471 ENST00000521846	E5RG43 [Direct mapping] Carbonic anhydrase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0005737 [cytoplasm] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] Show all	149 aa 16.4 kDa	No	0
CA1-005 ENSP00000430975 ENST00000523858	E5RGU8 [Direct mapping] Carbonic anhydrase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0005737 [cytoplasm] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] Show all	99 aa 11.2 kDa	No	0
CA1-006 ENSP00000427852 ENST00000522579	E5RG43 [Direct mapping] Carbonic anhydrase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0005737 [cytoplasm] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] Show all	149 aa 16.4 kDa	No	0
CA1-007 ENSP00000429688 ENST00000519129	E5RHS7 [Direct mapping] Carbonic anhydrase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		22 aa 2.6 kDa	No	0
CA1-010 ENSP00000429843 ENST00000517590	E5RH81 [Direct mapping] Carbonic anhydrase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0005737 [cytoplasm] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] Show all	176 aa 19.3 kDa	No	0
CA1-011 ENSP00000430571 ENST00000520663	E5RJF6 [Direct mapping] Carbonic anhydrase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0005737 [cytoplasm] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] Show all	87 aa 9.4 kDa	No	0
CA1-013 ENSP00000430737 ENST00000522814	E5RIF9 [Direct mapping] Carbonic anhydrase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0005737 [cytoplasm] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] Show all	148 aa 16.3 kDa	No	0
CA1-014 ENSP00000430372 ENST00000522662	E5RFL2 [Direct mapping] Carbonic anhydrase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0005737 [cytoplasm] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] Show all	118 aa 13.3 kDa	No	0
CA1-015 ENSP00000430861 ENST00000517618	E5RHP7 [Direct mapping] Carbonic anhydrase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0005737 [cytoplasm] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] Show all	251 aa 27.8 kDa	No	0
CA1-019 ENSP00000430543 ENST00000519991	E5RJI8 [Direct mapping] Carbonic anhydrase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0005737 [cytoplasm] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] Show all	138 aa 15.1 kDa	No	0
CA1-020 ENSP00000427773 ENST00000522389	E5RG81 [Direct mapping] Carbonic anhydrase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0005737 [cytoplasm] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] Show all	127 aa 14 kDa	No	0
CA1-021 ENSP00000428923 ENST00000524324	E5RFE7 [Direct mapping] Carbonic anhydrase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0005737 [cytoplasm] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] Show all	194 aa 21.4 kDa	No	0
CA1-022 ENSP00000429300 ENST00000521679	H0YBE2 [Direct mapping] Carbonic anhydrase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0005737 [cytoplasm] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] Show all	178 aa 19.7 kDa	No	0
CA1-201 ENSP00000392338 ENST00000431316	P00915 [Direct mapping] Carbonic anhydrase 1 V9HWE3 [Target identity:100%; Query identity:100%] Carbonic anhydrase I, isoform CRA_a; Epididymis secretory protein Li 11 Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004064 [arylesterase activity] GO:0004089 [carbonate dehydratase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] GO:0015701 [bicarbonate transport] GO:0016836 [hydro-lyase activity] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	261 aa 28.9 kDa	No	0
CA1-202 ENSP00000443517 ENST00000542576	P00915 [Direct mapping] Carbonic anhydrase 1 V9HWE3 [Target identity:100%; Query identity:100%] Carbonic anhydrase I, isoform CRA_a; Epididymis secretory protein Li 11 Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004064 [arylesterase activity] GO:0004089 [carbonate dehydratase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] GO:0015701 [bicarbonate transport] GO:0016836 [hydro-lyase activity] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	261 aa 28.9 kDa	No	0
CA1-203 ENSP00000486171 ENST00000626824	E5RG81 [Direct mapping] Carbonic anhydrase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0005737 [cytoplasm] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] Show all	127 aa 14 kDa	No	0