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CA1

GENERAL INFORMATION

Gene name

 CA1

Gene description

 Carbonic anhydrase I

Protein class

 Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 18
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (colorectal cancer, stomach cancer)
HPA (cell line):Cell line enriched (HEL)
HPA (normal tissue):Group enriched (bone marrow, colon, rectum)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic and nuclear expression in leukocytes and bone marrow, spleen and the large intestine.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA006558 , CAB025790
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (colorectal cancer, stomach cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA006558
CAB025790

GENE INFORMATION

Gene name

 CA1 (HGNC Symbol)

Synonyms

 Car1

Description

 Carbonic anhydrase I (HGNC Symbol)

Entrez gene summary

 Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This CA1 gene is closely linked to the CA2 and CA3 genes on chromosome 8. It encodes a cytosolic protein that is found at the highest level in erythrocytes. Allelic variants of this gene have been described in some populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Chromosome

 8

Cytoband

 q21.2

Chromosome location (bp)

 85327608 - 85379014

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000133742 (version 83.38)

Entrez gene

 759

UniProt

 P00915 (UniProt - Evidence at protein level)

neXtProt

 NX_P00915

Antibodypedia

 CA1 antibodies

PROTEIN BROWSER
«
CA1-001
CA1-003
CA1-004
CA1-005
CA1-006
CA1-007
CA1-010
CA1-011
CA1-013
CA1-014
CA1-015
CA1-019
CA1-020
CA1-021
CA1-022
CA1-201
CA1-202
CA1-203
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CA1-001
ENSP00000430656
ENST00000523953
P00915 [Direct mapping]
Carbonic anhydrase 1
V9HWE3 [Target identity:100%; Query identity:100%]
Carbonic anhydrase I, isoform CRA_a; Epididymis secretory protein Li 11
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Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004064 [arylesterase activity]
GO:0004089 [carbonate dehydratase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006730 [one-carbon metabolic process]
GO:0008270 [zinc ion binding]
GO:0015701 [bicarbonate transport]
GO:0016836 [hydro-lyase activity]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 261 aa
28.9 kDa 		No 0
CA1-003
ENSP00000429798
ENST00000523022
P00915 [Direct mapping]
Carbonic anhydrase 1
V9HWE3 [Target identity:100%; Query identity:100%]
Carbonic anhydrase I, isoform CRA_a; Epididymis secretory protein Li 11
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004064 [arylesterase activity]
GO:0004089 [carbonate dehydratase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006730 [one-carbon metabolic process]
GO:0008270 [zinc ion binding]
GO:0015701 [bicarbonate transport]
GO:0016836 [hydro-lyase activity]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 261 aa
28.9 kDa 		No 0
CA1-004
ENSP00000430471
ENST00000521846
E5RG43 [Direct mapping]
Carbonic anhydrase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004089 [carbonate dehydratase activity]
GO:0005737 [cytoplasm]
GO:0006730 [one-carbon metabolic process]
GO:0008270 [zinc ion binding]
Show all
 149 aa
16.4 kDa 		No 0
CA1-005
ENSP00000430975
ENST00000523858
E5RGU8 [Direct mapping]
Carbonic anhydrase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004089 [carbonate dehydratase activity]
GO:0005737 [cytoplasm]
GO:0006730 [one-carbon metabolic process]
GO:0008270 [zinc ion binding]
Show all
 99 aa
11.2 kDa 		No 0
CA1-006
ENSP00000427852
ENST00000522579
E5RG43 [Direct mapping]
Carbonic anhydrase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004089 [carbonate dehydratase activity]
GO:0005737 [cytoplasm]
GO:0006730 [one-carbon metabolic process]
GO:0008270 [zinc ion binding]
Show all
 149 aa
16.4 kDa 		No 0
CA1-007
ENSP00000429688
ENST00000519129
E5RHS7 [Direct mapping]
Carbonic anhydrase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 22 aa
2.6 kDa 		No 0
CA1-010
ENSP00000429843
ENST00000517590
E5RH81 [Direct mapping]
Carbonic anhydrase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004089 [carbonate dehydratase activity]
GO:0005737 [cytoplasm]
GO:0006730 [one-carbon metabolic process]
GO:0008270 [zinc ion binding]
Show all
 176 aa
19.3 kDa 		No 0
CA1-011
ENSP00000430571
ENST00000520663
E5RJF6 [Direct mapping]
Carbonic anhydrase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004089 [carbonate dehydratase activity]
GO:0005737 [cytoplasm]
GO:0006730 [one-carbon metabolic process]
GO:0008270 [zinc ion binding]
Show all
 87 aa
9.4 kDa 		No 0
CA1-013
ENSP00000430737
ENST00000522814
E5RIF9 [Direct mapping]
Carbonic anhydrase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004089 [carbonate dehydratase activity]
GO:0005737 [cytoplasm]
GO:0006730 [one-carbon metabolic process]
GO:0008270 [zinc ion binding]
Show all
 148 aa
16.3 kDa 		No 0
CA1-014
ENSP00000430372
ENST00000522662
E5RFL2 [Direct mapping]
Carbonic anhydrase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004089 [carbonate dehydratase activity]
GO:0005737 [cytoplasm]
GO:0006730 [one-carbon metabolic process]
GO:0008270 [zinc ion binding]
Show all
 118 aa
13.3 kDa 		No 0
CA1-015
ENSP00000430861
ENST00000517618
E5RHP7 [Direct mapping]
Carbonic anhydrase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004089 [carbonate dehydratase activity]
GO:0005737 [cytoplasm]
GO:0006730 [one-carbon metabolic process]
GO:0008270 [zinc ion binding]
Show all
 251 aa
27.8 kDa 		No 0
CA1-019
ENSP00000430543
ENST00000519991
E5RJI8 [Direct mapping]
Carbonic anhydrase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004089 [carbonate dehydratase activity]
GO:0005737 [cytoplasm]
GO:0006730 [one-carbon metabolic process]
GO:0008270 [zinc ion binding]
Show all
 138 aa
15.1 kDa 		No 0
CA1-020
ENSP00000427773
ENST00000522389
E5RG81 [Direct mapping]
Carbonic anhydrase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004089 [carbonate dehydratase activity]
GO:0005737 [cytoplasm]
GO:0006730 [one-carbon metabolic process]
GO:0008270 [zinc ion binding]
Show all
 127 aa
14 kDa 		No 0
CA1-021
ENSP00000428923
ENST00000524324
E5RFE7 [Direct mapping]
Carbonic anhydrase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004089 [carbonate dehydratase activity]
GO:0005737 [cytoplasm]
GO:0006730 [one-carbon metabolic process]
GO:0008270 [zinc ion binding]
Show all
 194 aa
21.4 kDa 		No 0
CA1-022
ENSP00000429300
ENST00000521679
H0YBE2 [Direct mapping]
Carbonic anhydrase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004089 [carbonate dehydratase activity]
GO:0005737 [cytoplasm]
GO:0006730 [one-carbon metabolic process]
GO:0008270 [zinc ion binding]
Show all
 178 aa
19.7 kDa 		No 0
CA1-201
ENSP00000392338
ENST00000431316
P00915 [Direct mapping]
Carbonic anhydrase 1
V9HWE3 [Target identity:100%; Query identity:100%]
Carbonic anhydrase I, isoform CRA_a; Epididymis secretory protein Li 11
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004064 [arylesterase activity]
GO:0004089 [carbonate dehydratase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006730 [one-carbon metabolic process]
GO:0008270 [zinc ion binding]
GO:0015701 [bicarbonate transport]
GO:0016836 [hydro-lyase activity]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 261 aa
28.9 kDa 		No 0
CA1-202
ENSP00000443517
ENST00000542576
P00915 [Direct mapping]
Carbonic anhydrase 1
V9HWE3 [Target identity:100%; Query identity:100%]
Carbonic anhydrase I, isoform CRA_a; Epididymis secretory protein Li 11
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004064 [arylesterase activity]
GO:0004089 [carbonate dehydratase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006730 [one-carbon metabolic process]
GO:0008270 [zinc ion binding]
GO:0015701 [bicarbonate transport]
GO:0016836 [hydro-lyase activity]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 261 aa
28.9 kDa 		No 0
CA1-203
ENSP00000486171
ENST00000626824
E5RG81 [Direct mapping]
Carbonic anhydrase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004089 [carbonate dehydratase activity]
GO:0005737 [cytoplasm]
GO:0006730 [one-carbon metabolic process]
GO:0008270 [zinc ion binding]
Show all
 127 aa
14 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.