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Several colorectal and prostate cancers along with a few cases of breast, ovarian, stomach and pancreatic cancers showed moderate to strong cytoplasmic positivity. Remaining cancers were generally negative.
This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provided by RefSeq, Jul 2008]