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LYVE1

GENERAL INFORMATION

Gene name

 LYVE1

Gene description

 Lymphatic vessel endothelial hyaluronan receptor 1

Protein class

 Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (adipose tissue, placenta)
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in lymphatic vessels.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

 Supported based on 2 antibodies.
HPA042953 , CAB025860
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Rectum

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adipose tissue, placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 LYVE1 (HGNC Symbol)

Synonyms

 LYVE-1, XLKD1

Description

 Lymphatic vessel endothelial hyaluronan receptor 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 p15.4

Chromosome location (bp)

 10556966 - 10611689

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000133800 (version 83.38)

Entrez gene

 10894

UniProt

 Q9Y5Y7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y5Y7

Antibodypedia

 LYVE1 antibodies

PROTEIN BROWSER
LYVE1-001
LYVE1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LYVE1-001
ENSP00000256178
ENST00000256178
Q9Y5Y7 [Direct mapping]
Lymphatic vessel endothelial hyaluronic acid receptor 1
B2R672 [Target identity:100%; Query identity:100%]
Extracellular link domain containing 1; cDNA PSEC0135 fis, clone PLACE1004850, highly similar to Homo sapiens extracellular link domain containing 1 (XLKD1), mRNA; cDNA, FLJ92817, highly similar to Homo sapiens extracellular link domain containing 1 (XLKD1), mRNA
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005540 [hyaluronic acid binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006027 [glycosaminoglycan catabolic process]
GO:0006810 [transport]
GO:0006928 [movement of cell or subcellular component]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007165 [signal transduction]
GO:0009611 [response to wounding]
GO:0009653 [anatomical structure morphogenesis]
GO:0016020 [membrane]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030214 [hyaluronan catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
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 322 aa
35.2 kDa 		Yes 1
LYVE1-003
ENSP00000436016
ENST00000529598
F2Z296 [Direct mapping]
Lymphatic vessel endothelial hyaluronic acid receptor 1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
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 218 aa
24 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.